Bing Sen Zhang

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The detection and characterization of unexpected disulfide-mediated structural variants of human immunoglobulin G2 (IgG2) antibodies was recently the subject of two copublications. In this paper, we present data to confirm the previously reported structures and elucidate the complete disulfide connectivity of each variant through the application of a novel(More)
In the present study, an adapted bacterium PF-11 with high 1,3-dichlorobenzene degradation capability was isolated from town-gas industrial effluent through continuous introducing of N-methyl-N'-nitro-N-nitrosoquanidine (NTG). In suitable condition, a degradation rate of 32 mg L(-1) d(-1) of 1,3-dichlorobenzene was obtained by strain PF-11 with effective(More)
We report the identification and characterization of a novel degradation product associated with PEGylation of a recombinant protein. After several months of storage at 2°C-8°C, an unexpected increase was observed in the proportion of an impurity that eluted with the native unPEGylated protein by size exclusion chromatography--from less than 0.01% at the(More)
We report the development and application of a method for determining bonding patterns in disulfide-linked peptides containing closely spaced cysteine residues. Through the utility of classic N-terminal sequencing chemistry coupled with facile liquid chromatography and mass spectrometric analysis of the cleavage products, we report the ability to(More)
Ketonic/quinonic C=O groups on the surface of a carbon matrix are capable of abstracting hydrogen in C=H bonds from hydrocarbons and enable them to selectively convert into corresponding unsaturated hydrocarbons; this process is the oxidative dehydrogenation (ODH) reaction. However, a variety of inevitable defects or graphene edges and other(More)
Telomerase is an important biomarker in cancer cells. It is active in germline cells, most of cancer tissues and cell lines, but not in most somatic tissues. Telomerase is composed of two components, and while hTER is present in normal and tumor cells, expression of hTERT appears to be highly regulated and correlates with telomerase activity. In order to(More)
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