Bing Liu

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A method which we call support vector machine with graded resolution (SVM-GR) is proposed in this paper. During the training of the SVM-GR, we first form data granules to train the SVM-GR and remove those data granules that are not support vectors. We then use the remaining training samples to train the SVM-GR. Compared with the traditional SVM, our SVM-GR(More)
Thailandepsin A is natural product of Burkholderia thailandensis E264 with potent histone deacetylase inhibitory activities and promising anticancer activities. The titer of thailandepsin A is very low (less than 10 mg/l) from limited empirical fermentation. To facilitate preclinical evaluations and potentially clinical development of thailandepsin A,(More)
3,3′,4′,5-Tetrachlorosalicylanilide (TCS) is an effective metabolic uncoupler utilized for microbial yield reduction. However, its potential impact, in particular on the soluble microbial products (SMP) formation, is unknown yet. Herein we study the effect of TCS on SMP production and analyze the related mechanism. The addition of TCS in activated sludge(More)
Two new compounds, the 6-oxo oleanane-type triterpenoid uncarilic acid, and its 5,6-secotriterpenoid derivative, secouncarilic acid, were isolated from the hooks and stems of Uucaria sessilifructus together with seven known ursane-type triterpenoids. Uncarilic acid is the second 6-oxo oleanane-type triterpenoid ever reported, while secouncarilic acid is the(More)
The asymmetric unit of the title compound, C(3)H(4)N(4)O(2)·0.5H(2)O, comprises two whole mol-ecules of 5-amino-1H-1,2,4-triazole-3-carb-oxy-lic acid in its zwitterionic form (proton transfer occurs from the carb-oxy-lic acid group to the N hetero-atom at position 1), plus one water mol-ecule of crystallization. The organic moieties are disposed into(More)
The synthesis and structural characterization of five transition metal complexes with different dimensionality and incorporating residues of 3-amino-1H-1,2,4-triazole-5-carboxylic acid (H2atrc) is reported: [Zn(Hatrc)2(H2O)] (1), [Mn(Hatrc)2(H2O)2]·2H2O (2), [Fe2(Hatrc)4(OH)2]·6H2O (3), [Cd(Hatrc)2(H2O)]n (4), and [Mn(atrc)(H2O)]n·nH2O (5). These materials(More)
In this paper, we investigate the linear solver in least square support vector machine (LSSVM) for large-scale data regression. The traditional methods using the direct solvers are costly. We know that the linear equations should be solved repeatedly for choosing appropriate parameters in LSSVM, so the key for speeding up LSSVM is to improve the method of(More)
Both the 3-amino-2H,4H-1,2,4-triazolium cation and the pyrazine-2-carboxyl-ate anion in the title salt, C2H5N4 (+)·C5H3N2O2 (-), were formed by an unexpected deca-rboxylation reaction, from 5-amino-1H-1,2,4-triazole-3-carb-oxy-lic acid and pyrazine-2,3-di-carb-oxy-lic acid, respectively. The dihedral angle between the pyrazine ring (r.m.s. deviation = 0.008(More)
Progenin III, one of the most active spirostanol saponins, is a potential candidate for anti-cancer therapy due to its strong antitumor activity and low hemolytic activity. However, the concentration of progenin III is extremely low in natural Dioscorea plants. In this paper, the progenin III production from total steroidal saponins of Dioscorea nipponica(More)