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The Role of Chromatin during Transcription
Chromatin structure imposes significant obstacles on all aspects of transcription that are mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated through multipleExpand
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Histone H3 Methylation by Set2 Directs Deacetylation of Coding Regions by Rpd3S to Suppress Spurious Intragenic Transcription
Yeast Rpd3 histone deacetylase plays an important role at actively transcribed genes. We characterized two distinct Rpd3 complexes, Rpd3L and Rpd3S, by MudPIT analysis. Both complexes shared a threeExpand
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Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
THE development of new blood vessels (angiogenesis) is required for many physiological processes including embryogenesis, wound healing and corpus luteum formation1,2. Blood vessel neoformation isExpand
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Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes.
The decision by a cell to enter a round of growth and division must be intimately coordinated with nutrient availability and its metabolic state. These metabolic and nutritional requirements, and theExpand
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Combined Action of PHD and Chromo Domains Directs the Rpd3S HDAC to Transcribed Chromatin
Nucleosomes must be deacetylated behind elongating RNA polymerase II to prevent cryptic initiation of transcription within the coding region. RNA polymerase II signals for deacetylation through theExpand
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Infrequently transcribed long genes depend on the Set2/Rpd3S pathway for accurate transcription.
The presence of Set2-mediated methylation of H3K36 (K36me) correlates with transcription frequency throughout the yeast genome. K36me targets the Rpd3S complex to deacetylate transcribed regions andExpand
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SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.
Members of sirtuin family regulate multiple critical biological processes, yet their role in carcinogenesis remains controversial. To investigate the physiological functions of SIRT2 in developmentExpand
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Cse4 is part of an octameric nucleosome in budding yeast.
The budding yeast CenH3 histone variant Cse4 localizes to centromeric nucleosomes and is required for kinetochore assembly and chromosome segregation. The exact composition of centromericExpand
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Scm3 is essential to recruit the histone h3 variant cse4 to centromeres and to maintain a functional kinetochore.
The kinetochore is a complex multiprotein structure located at centromeres that is essential for proper chromosome segregation. Budding-yeast Cse4 is an essential evolutionarily conserved histone H3Expand
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Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling.
The yeast histone variant H2AZ (Htz1) is implicated in transcription activation, prevention of the ectopic spread of heterochromatin, and genome integrity. Our genome-wide localization analysisExpand
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