Learn More
Electrophysiological studies have shown the enhanced response of anterior cingulate cortex (ACC) to colorectal distension in viscerally hypersensitive (VH) rats, which can be observed up to 7 weeks following colonic anaphylaxis, independent of colon inflammation, suggesting a mechanism for learning and triggering of pain memories in the ACC neuronal(More)
Studies of both humans and animals suggest that anterior cingulate cortex (ACC) is important for processing pain perception. We identified that perigenul ACC (pACC) sensitization and enhanced visceral pain in a visceral hypersensitive rat in previous studies. Pain contains both sensory and affective dimensions. Teasing apart the mechanisms that control the(More)
Prenatal morphine exposure induces neurobiological changes, including deficits in learning and memory, in juvenile rat offspring. However the effects of this exposure on hippocampal plasticity, which is critical for learning and memory processes, are not well understood. The present study investigates the alterations of spatial memory and in vivo(More)
Ciguatoxins (CTXs) cause long-term disturbance of cerebral functions. The primary mechanism of neurotoxicity is related to their interaction with voltage-gated sodium channels. However, until now, the neurological targets for CTXs in the brain of intact animals have not been described. In our study, 1 day following oral exposure to 0.26 ng/g of Pacific(More)
The NR2B subunit of NMDA receptor in the anterior cingulate cortex (ACC) is up-regulated in viscerally hypersensitive (VH) rats induced by colonic anaphylaxis. It plays a critical role in modulation of ACC sensitization and visceral pain responses. Given the key role of calcium/calmodulin-dependent protein kinase II (CaMKII) in synaptic plasticity and(More)
A mathematical model is derived to simulate the performance of spiral wound membrane modules for the pervaporative separation of binary liquid mixtures. Permeation through the polymer membrane is described by a detailed solution–diffusion model. Flory–Huggins theory is used to predict solubility of the penetrants, while the composition and temperature(More)
Imatinib, an orally administered tyrosine kinase inhibitor of PDGF receptor, c-abl and c-kit, is currently in clinical trials to assess its efficacy in malignant gliomas. Although imatinib does not readily penetrate an intact blood-brain barrier (BBB), the extent to which it distributes into regions of high grade gliomas where the BBB is compromised has not(More)
  • Bing Cao, Richard Farr, Mike Byrne, James Tannock
  • 2005
With the ever-increasing complexity and dynamics of supply chains in an extended enterprise, simulation has become a powerful tool to assess supply performance. In traditional simulation approaches, a model is constructed by a user, who defines it step-by-step via the user interface of the simulation tool. However, if the model configuration needs to be(More)
  • Chang-Seop Kim, James Tannock, Mike Byrne, Richard Farr, Bing Cao, Mahendrawathi Er
  • 2005
This document describes how simulation tools might be applied to investigate logistics at both the extended enterprise level, and the internal, company level. Supply chain modelling and management are discussed, and metrics are proposed whereby the efficiency of a conceptual enterprise might be assessed. The concept of data-driven simulation is introduced,(More)
Within a biopsychosocial model of pain, pain is seen as a conscious experience modulated by mental, emotional and sensory mechanisms. Recently, using a rodent visceral pain assay that combines the colorectal distension (CRD) model with the conditioned place avoidance (CPA) paradigms, we measured a learned behavior that directly reflects the affective(More)