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Significant survival benefit of adjuvant chemotherapy after concurrent chemoradiotherapy in locally advanced high-risk nasopharyngeal carcinoma
TLDR
High-risk patients with loco-regionally advanced nasopharyngeal carcinoma may benefit from the addition of AC to CCRT regarding OS, according to a prognostic model created. Expand
Cofilin-2 Acts as a Marker for Predicting Radiotherapy Response and Is a Potential Therapeutic Target in Nasopharyngeal Carcinoma
TLDR
The findings suggest that cofilin-2 acts as a marker for predicting radiotherapy response and is a potential therapeutic target in nasopharyngeal carcinoma. Expand
Silencing of c-jun decreases cell migration, invasion, and EMT in radioresistant human nasopharyngeal carcinoma cell line CNE-2R
TLDR
It is suggested that silencing of c-jun in CNE-2R cells reduces cells migration, invasion, and EMT both in vitro and in vivo. Expand
The role of autophagy in the radiosensitivity of the radioresistant human nasopharyngeal carcinoma cell line CNE-2R
TLDR
The autophagy level is negatively correlated with radiosensitivity for the radio-resistant human nasopharyngeal carcinoma cell line CNE-2R. Expand
Cancer stem cell‐like characteristics and telomerase activity of the nasopharyngeal carcinoma radioresistant cell line CNE‐2R
TLDR
This work provides a foundation for future studies on stem cell‐targeted therapies by targeting the radioresistance of NPC by exploring the CSC‐like characteristics and telomerase activity of the NPC radioresistant cell line CNE‐2R. Expand
Reduced QSOX1 enhances radioresistance in nasopharyngeal carcinoma
TLDR
The shRNA-mediated knockdown of QSOX1 significantly increased cell survival under irradiation (IR) and weakened radiosensitivity, which was likely due to a reduction in the cell apoptosis rate after IR. Expand
The Double-Edge Role of the Addition of Adjuvant Chemotherapy to Concurrent Chemoradiotherapy in the Treatment of Nasopharyngeal Carcinoma
TLDR
Internal and external validation showed that the discrimination of the PI for OS was significantly better than that of the 8th edition AJCC staging system, and the proposed prognostic model achieved good prediction and calibration of OS for patients with NPC. Expand
A positive feedback loop between Wnt/β‐catenin signaling and hTERT regulates the cancer stem cell‐like traits in radioresistant nasopharyngeal carcinoma cells
TLDR
A positive feedback loop between Wnt/β‐catenin signaling and hTERT in CNE‐2R cells, which can regulate the telomerase activity and CSC‐like traits, thus regulating the radiosensitivity is outlined. Expand
Clinical usefulness of 18F-FDG PET/CT for the detection of distant metastases in patients with non-small cell lung cancer at initial staging: a meta-analysis
TLDR
18F-FDG PET/CT has a good diagnostic performance for distant metastasis staging in patients with NSCLC at initial staging. Expand
Downregulation of CD166 inhibits invasion, migration, and EMT in the radio-resistant human nasopharyngeal carcinoma cell line CNE-2R
TLDR
In vivo metastasis test proved that knockdown of CD166 suppressed pulmonary metastasis and liver metastasis according to hematoxylin and eosin (H&E) staining. Expand
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