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PURPOSE Intensity modulated radiation therapy (IMRT) treatment plan quality depends on the planner's level of experience and the amount of time the planner invests in developing the plan. Planners often unwittingly accept plans when further sparing of the organs at risk (OARs) is possible. The authors propose a method of IMRT treatment plan quality control(More)
PURPOSE To propose a method of intensity-modulated radiotherapy (IMRT) planning that generates achievable dose-volume histogram (DVH) objectives using a database containing geometric and dosimetric information of previous patients. METHODS AND MATERIALS The overlap volume histogram (OVH) is used to compare the spatial relationships between the organs at(More)
PURPOSE To assess volumetric changes of selected organs at risk (OAR) during intensity-modulated radiotherapy (IMRT) for oropharyngeal carcinoma. MATERIALS AND METHODS Twenty-six consecutive patients that were treated with definitive IMRT ± chemotherapy between November 2007 and November 2008 were selected for the present study. As part of an internal(More)
PURPOSE To prospectively determine whether overlap volume histogram (OVH)-driven, automated simultaneous integrated boosted (SIB)-intensity-modulated radiation therapy (IMRT) treatment planning for head-and-neck cancer can be implemented in clinics. METHODS AND MATERIALS A prospective study was designed to compare fully automated plans (APs) created by an(More)
The task of IMRT planning, particularly in head-and-neck cancer, is a difficult one, often requiring days of work from a trained dosimetrist. One of the main challenges is the prescription of achievable target doses that will be used to optimize a treatment plan. This work explores a data-driven approach in which effort spent on past plans is used to assist(More)
AIMS To investigate dosimetric predictors of voice changes after whole-field intensity-modulated radiotherapy (IMRT). MATERIALS AND METHODS Patients treated with whole-field IMRT for oropharyngeal/unknown primary tumours were selected for the present retrospective study having grossly uninvolved larynx at the time of radiotherapy and at least one(More)
BACKGROUND Volatile anesthetics are widely used in pediatric anesthesia but their potential neurotoxicity raise significant concerns regarding sequelae after anesthesia. However, whether physiological disturbance during anesthetic exposure contributes to such side effects remains unknown. The aim of the current study is to compare the neurotoxic effects of(More)
PURPOSE To investigate the roles of volumetric modulated arc therapy with SmartArc (VMAT-S), intensity-modulated radiation therapy (IMRT), and helical tomotherapy (HT) for oropharyngeal cancer using a simultaneous integrated boost (SIB) approach. METHODS AND MATERIALS Eight patients treated with IMRT were selected at random. Plans were computed for both(More)
In this paper we address the challenge of matching patient geometry to facilitate the design of patient treatment plans in radiotherapy. To this end we propose a novel shape descriptor, the Overlap Volume Histogram, which provides a rotation and translation invariant representation of a patient's organs at risk relative to the tumor volume. Using our(More)
PURPOSE To define the roles of radiotherapy and chemotherapy on the risk of Grade 3+ mucositis during intensity-modulated radiation therapy (IMRT) for oropharyngeal cancer. METHODS AND MATERIALS 164 consecutive patients treated with IMRT at two institutions in nonoverlapping treatment eras were selected. All patients were treated with a dose painting(More)