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PURPOSE Intensity modulated radiation therapy (IMRT) treatment plan quality depends on the planner's level of experience and the amount of time the planner invests in developing the plan. Planners often unwittingly accept plans when further sparing of the organs at risk (OARs) is possible. The authors propose a method of IMRT treatment plan quality control(More)
PURPOSE To investigate the roles of volumetric modulated arc therapy with SmartArc (VMAT-S), intensity-modulated radiation therapy (IMRT), and helical tomotherapy (HT) for oropharyngeal cancer using a simultaneous integrated boost (SIB) approach. METHODS AND MATERIALS Eight patients treated with IMRT were selected at random. Plans were computed for both(More)
Stem cells are responsible for organogenesis, but it is largely unknown whether and how information from stem cells acts to direct organ patterning after organ primordia are formed. It has long been proposed that the stem cells at the plant shoot apex produce a signal, which promotes leaf adaxial-abaxial (dorsoventral) patterning. Here we show the existence(More)
The task of IMRT planning, particularly in head-and-neck cancer, is a difficult one, often requiring days of work from a trained dosimetrist. One of the main challenges is the prescription of achievable target doses that will be used to optimize a treatment plan. This work explores a data-driven approach in which effort spent on past plans is used to assist(More)
PURPOSE To assess volumetric changes of selected organs at risk (OAR) during intensity-modulated radiotherapy (IMRT) for oropharyngeal carcinoma. MATERIALS AND METHODS Twenty-six consecutive patients that were treated with definitive IMRT ± chemotherapy between November 2007 and November 2008 were selected for the present study. As part of an internal(More)
PURPOSE To propose a method of intensity-modulated radiotherapy (IMRT) planning that generates achievable dose-volume histogram (DVH) objectives using a database containing geometric and dosimetric information of previous patients. METHODS AND MATERIALS The overlap volume histogram (OVH) is used to compare the spatial relationships between the organs at(More)
PURPOSE To prospectively determine whether overlap volume histogram (OVH)-driven, automated simultaneous integrated boosted (SIB)-intensity-modulated radiation therapy (IMRT) treatment planning for head-and-neck cancer can be implemented in clinics. METHODS AND MATERIALS A prospective study was designed to compare fully automated plans (APs) created by an(More)
PURPOSE To develop a model to assess the quality of an IMRT treatment plan using data of prior patients with pancreatic adenocarcinoma. METHODS The dose to an organ at risk (OAR) depends in large part on its orientation and distance to the planning target volume (PTV). A database of 33 previously treated patients with pancreatic cancer was queried to find(More)
To investigate the feasibility of using biochar to control organic pollutants in sediments, we extracted biochar from rice-straw combustion residues (RBC) and studied its adsorption ability and effect on seed germination ecotoxicity of pentachlorophenol (PCP). The results showed that the Freundlich and dual-mode models could describe all the sorption(More)
In this paper we address the challenge of matching patient geometry to facilitate the design of patient treatment plans in radiotherapy. To this end we propose a novel shape descriptor, the Overlap Volume Histogram, which provides a rotation and translation invariant representation of a patient's organs at risk relative to the tumor volume. Using our(More)