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Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis with potential for progression to acute myeloid leukemia (AML). We compared natural killer (NK) cytolytic function in 48 MDS patients with 37 healthy donors and found reduced activity in the patient population (K562 cytolysis, 19% +/- 21% SD versus 40% +/- 17%) (P < .001). NK(More)
The mitogen-activated protein kinase–extracellular signal–regulated kinase signaling element (MAPK-ERK) plays a critical role in natural killer (NK) cell lysis of tumor cells, but its upstream effectors were previously unknown. We show that inhibition of phosphoinositide-3 kinase (PI3K) in NK cells blocks p21-activated kinase 1 (PAK1), MAPK kinase (MEK) and(More)
The performance analysis of optimal relay decode-and-forward (DF) selection for both the full-duplex (FD) and half-duplex (HD) relaying modes is studied, with some important factors such as the distributions of the received signal-to-noise ratio (SNR), the outage probability and the average channel capacity, etc., being taken into account. Different from(More)
Interleukin-2 (IL-2) prevents cell apoptosis and promotes survival, but the involved mechanisms have not been completely defined. Although phosphatidylinositide 3-kinase (PI 3-kinase) has been implicated in IL-2-mediated survival mechanisms, none of the 3 chains of the IL-2 receptor (IL-2R) expresses a binding site for PI 3-kinase. However, IL-2Rbeta does(More)
BACKGROUND The purpose of this study was to compare the efficacy of radiofrequency catheter ablation (RFCA) versus antiarrhythmic drugs (AADs) for treatment of patients with frequent ventricular premature beats (VPBs) originating from the right ventricular outflow tract (RVOT). METHODS AND RESULTS A total of 330 eligible patients were included in the(More)
One of the major obstacles in curing prostate cancer is the development of drug resistance to docetaxel, which is the gold standard for the treatment of this disease. It is not only imperative to discover the molecular basis of resistance but also to find therapeutic agents that can disrupt the resistant pathways. Based on initial findings that(More)
The performance analysis of optimal decode-and-forward (DF) relay selection for the full-duplex (FD) mode in underlay cognitive radio (CR) networks is studied, with the impact of critical parameters such as the residual self-interference, the distributions of the received signal-to-noise ratio (SNR), and the outage probability, being analyzed. Different(More)
Emerging evidence suggests that NK-activatory receptors use KARAP/DAP12, CD3zeta, and FcepsilonRIgamma adaptors that contain immunoreceptor tyrosine-based activatory motifs to mediate NK direct lysis of tumor cells via Syk tyrosine kinase. NK cells may also use DAP10 to drive natural cytotoxicity through phosphoinositide 3-kinase (PI3K). In contrast to our(More)
The impact of an imperfect channel estimation on the amplify-and-forward (AF) mode cooperative communications systems is studied, with some important factors, including the probability characteristic of the secondary user's end-to-end signal-to-noise ratio (SNR), the outage probability, the symbol error probability (SEP), and the channel capacity, being(More)
The secrecy outage probability (SOP) of cooperative communication systems with optimal relay selection (ORS) scheme in the presence of an eavesdropper is investigated by implementing decode-and-forward-based full-duplex (FD) two-way relayingmode. Under Rayleigh fading assumptions, the closed-form expressions for the distributions of end-to-end(More)