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Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2-dependent regulatory dendritic cell population.
TLDR
It is reported that MSCs vigorously promote proliferation of maDCs, significantly reduce their expression of Ia, CD11c, CD80, CD86, and CD40 while increasing CD11b expression, and it is found that M SCs, partly via cell-cell contact, driveMaDCs to differentiate into a novel Jagged-2-dependent regulatory DC population and escape their apoptotic fate. Expand
Clinical significance of IL-18 gene over-expression in AML.
TLDR
Observations suggest that IL-18 gene over-expression might reflect the convergence of several important unfavorable prognostic factors in AML. Expand
IL-18 increases invasiveness of HL-60 myeloid leukemia cells: up-regulation of matrix metalloproteinases-9 (MMP-9) expression.
TLDR
It is postulate that IL-18 may in part play a role in the clinical aggressiveness of human myeloid leukemia by stimulating MMP-9 production. Expand
TGF-beta1-induced PI3K/Akt/NF-kappaB/MMP9 signalling pathway is activated in Philadelphia chromosome-positive chronic myeloid leukaemia hemangioblasts.
TLDR
Findings provide direct evidence for the first time that hemangioblasts beyond HSCs play a critical role in the progression of CML. Expand
Expression and regulation of interleukin‐23 subunits in human peripheral blood mononuclear cells and hematopoietic cell lines in response to various inducers
TLDR
The results suggest that both the subunits of IL‐23 are tightly regulated; the expression pattern and regulation mode ofIL‐23 p19 is similar to as well as distinct from that of IL-12 p35. Expand
Expression and production of bioactive human interleukin-18 in transgenic tobacco plants
The cDNA of human interleukin-18 (hIL-18) was successfully inserted into the genome of tobacco plant, Nicotiana tabacum cv. NC-89, using Agrobacterium tumefaciens-mediated transformation. InsertionExpand
Human adipose tissue-derived mesenchymal stem cells facilitate the immunosuppressive effect of cyclosporin A on T lymphocytes through Jagged-1-mediated inhibition of NF-κB signaling.
TLDR
Human AMSCs facilitate the immunosuppressive effect of CsA on T lymphocytes through Jagged-1/Notch-related inhibition of NF-κB signaling. Expand
Expression of LL-37/hCAP-18 gene in human leukemia cells.
TLDR
The data suggested that the low translation efficiency of LL-37/hCAP-18 expresses in some leukemia cells might be one of the reasons that leukemia patients were susceptible to infection. Expand
Expression of IL-18 and its receptor in human leukemia cells.
TLDR
The results revealed that IL-18 mRNA was expressed in eight human hematopoietic cell lines representing different lineages and neoplasms including leukemia, lymphoma and others and the effective modulating effect of M-CSF, IFN-alpha and TNF-alpha on IL- 18R expression, implying an important in vivo effect of cytokines onIL-18-induced reaction. Expand
Expression and significance of IL-18 in the bone marrow of patients with hematological diseases.
TLDR
IL-18 was detected at elevated levels in the bone marrow of patients with some hematological malignancies, and might be involved in the proliferation of certain leukemic cells in vivo through an autocrine mechanism. Expand
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