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Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing
TLDR
A novel, rapid, digital PCR–based assay that can simultaneously detect one HDR or NHEJ event out of 1,000 copies of the genome will enable mechanistic studies of genome-editing and help improve genome-EDiting technology.
Neural tube opening and abnormal extraembryonic membrane development in SEC23A deficient mice
TLDR
It is reported that E-cadherin is a cargo that accumulates in acini ofSEC23B deficient pancreas and salivary glands, suggesting that mammalian SEC23A and SEC23B transport overlapping yet distinct spectra of cargo in vivo.
Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia
TLDR
Hh pathway inhibition, in combination with nilotinib, is identified as a potentially effective therapeutic strategy to improve responses in CP-CML by targeting both stem and progenitor cells.
A Strategy to Delay the Development of Cisplatin Resistance by Maintaining a Certain Amount of Cisplatin-Sensitive Cells
TLDR
A mathematical model parameterized based on in vivo experiments to describe the allometric growth of tumors consisting of two competing subclones is proposed to control tumor growth and could remarkably delay the development of ddp resistance and prolong overall survival.
Vacancy Structures and Melting Behavior in Rock-Salt GeSbTe
TLDR
The observation of multi-rock-salt phases suggests another route for multi-level data storage using GeSbTe, and first-principles calculations reveal that the phase transition is an energetically favored process.
Mechanisms of Gefitinib-mediated reversal of tamoxifen resistance in MCF-7 breast cancer cells by inducing ERα re-expression
TLDR
Gefitinib reverses TAM resistance primarily by up-regulating the ERα mRNA level and inducing the re- expression of ERα, and the MAPK pathway plays a key role in ERα re-expression.
Characterization of a major QTL for manganese accumulation in rice grain
TLDR
This study cloned a major QTL for grain Mn concentration in rice, and identified materials for breeding rice for high Mn and low Cd concentrations in the grain.
Hybrid Dielectric-loaded Nanoridge Plasmonic Waveguide for Low-Loss Light Transmission at the Subwavelength Scale
TLDR
The hybrid dielectric-loaded nanoridge plasmonic platform may serve as a fundamental building block for various functional photonic components and be used in applications such as sensing, nanofocusing, and nanolasing.
Pancreatic SEC23B deficiency is sufficient to explain the perinatal lethality of germline SEC23B deficiency in mice
TLDR
It is demonstrated that SEC23B but not SEC23A is essential for murine pancreatic development and two BAC transgenes spanning Sec23b rescue the lethality of mice homozygous for aSec23b gene trap allele, indicating that the regulatory elements critical for Sec23B pancreatic function reside within the BACtransgenes.
Missense mutations near the N-glycosylation site of the A2 domain lead to various intracellular trafficking defects in coagulation factor VIII
TLDR
It is shown that the short 310-helix from D580 to S584 is critical for proper biogenesis of the A2 domain and FV III, and a range of molecular mechanisms by which FVIII missense mutations lead to moderate to severe hemophilia A are revealed.
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