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Sex differences in insomnia: a meta-analysis.
A meta-analysis confirmed a female predisposition of insomnia, which was consistent and progressive across age, with more significance in the elderly, and there was a relatively lower female excess in East Asia.
Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary disease.
Association of selective and conventional nonsteroidal antiinflammatory drugs with acute renal failure: A population-based, nested case-control analysis.
- V. Schneider, L. Lévesque, Bin Zhang, T. Hutchinson, J. Brophy
- MedicineAmerican journal of epidemiology
- 1 November 2006
There was a significant association for both selective and nonselective NSAIDs with acute renal failure, but confirmatory studies are required.
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
This is the first study to demonstrate that chronic clearance of senescent cells improves established vascular phenotypes associated with aging and chronic hypercholesterolemia, and may be a viable therapeutic intervention to reduce morbidity and mortality from cardiovascular diseases.
The Risk for Myocardial Infarction With Cyclooxygenase-2 Inhibitors: A Population Study of Elderly Adults
Evidence is provided of an increased risk for acute MI in current users of rofecoxib among elderly persons with no history of MI, and this risk appears greater at higher doses.
Brief physician-initiated quit-smoking strategies for clinical oncology settings: a trial coordinated by the Eastern Cooperative Oncology Group.
- R. Schnoll, Bin Zhang, P. Engstrom
- MedicineJournal of clinical oncology : official journal…
- 15 January 2003
While training physicians to provide smoking cessation treatment to cancer patients can enhance physician adherence to clinical practice guidelines, physician smoking cessation interventions fail to yield significant gains in long-term quit rates among cancer patients.
Autoantibodies to Agrin in Myasthenia Gravis Patients
Sera from MG patients with agrin antibodies were able to recognize recombinant agrin in conditioned media and in transfected HEK293 cells and inhibited the agrin-induced MuSK phosphorylation and AChR clustering in muscle cells, indicating that agrin is another autoantigen in patients with MG and agrin autoantibodies may be pathogenic through inhibition of agrin/LRP4/MuSK signaling at the NMJ.
Activating Structural Alterations in MAPK Genes Are Distinct Genetic Drivers in a Unique Subgroup Of Spitzoid Neoplasms
A distinct subtype of Spitzoid neoplasm is presented characterized by structural alterations in MAPK genes, which are important to recognize given the potential for treatment with MAPK inhibitors in metastatic cases.
Prognostic value of platelet to lymphocyte ratio in non-small cell lung cancer: a systematic review and meta-analysis
- Hua Zhang, Liuwei Gao, Bin Zhang, Lianmin Zhang, Changli Wang
- Biology, MedicineScientific reports
- 4 March 2016
This meta-analysis indicates that a high PLR might be a predictive factor of poor prognosis in NSCLC, and patients with an elevated PLR are expected to have a shorter overall survival after treatment.
Investigation of elemene-induced reversal of tamoxifen resistance in MCF-7 cells through oestrogen receptor α (ERα) re-expression
- Bin Zhang, Xia Zhang, Bo Tang, Peishi Zheng, Yang Zhang
- BiologyBreast Cancer Research and Treatment
- 30 September 2012
It is discovered that treatment with 10 μg/ml ELE restored the sensitivity of MCF7/TAM cells to TAM, and the ELE-induced reversal of TAM resistance was mediated by the upregulation of ER α mRNA and the re-expression of ERα through the MAPK pathway.