Learn More
PhosphoSitePlus (http://www.phosphosite.org) is an open, comprehensive, manually curated and interactive resource for studying experimentally observed post-translational modifications, primarily of human and mouse proteins. It encompasses 1,30,000 non-redundant modification sites, primarily phosphorylation, ubiquitinylation and acetylation. The interface is(More)
PhosphoSite is a curated, web-based bioinformatics resource dedicated to physiologic sites of protein phosphorylation in human and mouse. PhosphoSite is populated with information derived from published literature as well as high-throughput discovery programs. PhosphoSite provides information about the phosphorylated residue and its surrounding sequence,(More)
PhosphoSitePlus(®) (PSP, http://www.phosphosite.org/), a knowledgebase dedicated to mammalian post-translational modifications (PTMs), contains over 330,000 non-redundant PTMs, including phospho, acetyl, ubiquityl and methyl groups. Over 95% of the sites are from mass spectrometry (MS) experiments. In order to improve data reliability, early MS data have(More)
Dynamic and partial reconfiguration (DPR) is a special feature offered by Xilinx Field Programmable Gate Arrays (FPGAs), giving the designer the ability to reconfigure a certain portion of the FPGA during run-time without influencing the other parts. This feature allows the hardware to be adaptable to any potential situation. For some applications, such as(More)
The pregnane X receptor (PXR; NR1I2), a member of the nuclear receptor superfamily, regulates the expression of drug-metabolic enzymes and transporters involved in the responses of mammals to their chemical environment. The same enzyme and transporter systems are also involved in the homeostasis of numerous endogenous chemicals. The regulatory function of(More)
PDS5B is a sister chromatid cohesion protein that is crucial for faithful segregation of duplicated chromosomes in lower organisms. Mutations in cohesion proteins are associated with the developmental disorder Cornelia de Lange syndrome (CdLS) in humans. To delineate the physiological roles of PDS5B in mammals, we generated mice lacking PDS5B (APRIN).(More)
The Fc receptor CD16 is present on essentially all CD56(dim) peripheral blood natural killer (NK) cells. Upon recognition of antibody-coated cells it delivers a potent signal to NK cells, which eliminate targets through direct killing and cytokine production. Here we investigated the regulation of CD16 surface expression after NK cell activation. Cytokine(More)
There is a large number of scanned historical documents that need to be indexed for archival and retrieval purposes. A visual word spotting scheme that would serve these purposes is a challenging task even when the transcription of the document image is available. We propose a framework for mapping each word in the transcript to the associated word image in(More)
In this paper, we experimentally realized a steering antenna using a type of active metamaterial with tunable refractive index. The metamaterial is realized by periodically printed subwavelength metallic resonant patterns with embedded microwave varactors. The effective refractive index can be controlled by low direct-current (dc) bias voltage applied to(More)
Wireless sensor networks (WSN) will enable the reliable monitoring of a variety environment for both civil and military applications. These networks require robust wireless communication protocols for the purpose of balancing the load and prolonging the network lifetime. In this paper, we propose a novel hierarchical routing protocol based on artificial(More)