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Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage
GSDMD-induced pyroptosis mediated by the AIM2 inflammasome may be involved in early brain injury (EBI) after subarachnoid haemorrhage (SAH), and apoptosis was significantly suppressed via impeding the activation of caspase-3. Expand
Inhibition of Elevated Hippocampal CD24 Reduces Neurogenesis in Mice With Traumatic Brain Injury.
The results indicated that both mRNA and protein levels of CD24 were markedly elevated in the hippocampus after TBI, and suggested that hippocampal expression ofCD24 might positively regulate neurogenesis and improve cognitive functions after TBO. Expand
Receptor-Mediated Delivery of Astaxanthin-Loaded Nanoparticles to Neurons: An Enhanced Potential for Subarachnoid Hemorrhage Treatment
Improved bioavailability and enhanced neuroprotective effects enabled ATX-NPs as favorable candidates for targeted delivery and absorption of ATX, and will provide insights for advancement of subarachnoid hemorrhage therapy. Expand
Morphology parameters for rupture in middle cerebral artery mirror aneurysms
- Wei-dong Xu, Han-Dong Wang, +6 authors X. Zhang
- Journal of NeuroInterventional Surgery
- 27 February 2020
Aneurysm width, AR and anterior dome projection were independent risks factors of rupture of middle cerebral artery (MCA) aneurysms. Expand
Feasibility study of astaxanthin-loaded nanoparticles targeting neurons
Objective In order to improve the problems about poor water solubility of astaxanthin (ATX), Fe3O4 nanoparticles (NPs) were used to encapsulate ATX and evaluate its targeted aggregation by cortical… Expand
Safety and efficacy of different therapeutic strategies in the endovascular treatment of anterior cerebral artery aneurysms with different features: A single centre experience
- Bin Yuan, Xiao-ming Zhou, +7 authors X. Zhang
- Clinical Neurology and Neurosurgery
- 16 March 2020
Endovascular treatment is feasible and effective for ACA aneurysms and higher Hunt-Hess grade was an independent risk factor for poor clinical outcome. Expand
Correlation between Vascular Geometry Changes and Long-term Outcomes after Enterprise Stent Deployment for Intracranial Aneurysms Located on Small Arteries.
This study found that Enterprise deployment in small arteries had a low procedural complication rate and high stent tolerance, and stent-assisted coiling of intracranial aneurysms located on small arteries is safe and effective. Expand