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  • BY NICOLAI MEINSHAUSEN, Bin Yu
  • 2006
The Lasso is an attractive technique for regularization and variable selection for high-dimensional data, where the number of predictor variables pn is potentially much larger than the number of samples n. However, it was recently discovered that the sparsity pattern of the Lasso estimator can only be asymptotically identical to the true sparsity pattern if(More)
We previously developed a social mechanism for distributed reputation management, in which an agent combines testimonies from several witnesses to determine its ratings of another agent. However, that approach does not fully protect against spurious ratings generated by malicious agents. This paper focuses on the problem of deception in testimony(More)
Small RNAs of 21-25 nucleotides (nt), including small interfering RNAs (siRNAs) and microRNAs (miRNAs), act as guide RNAs to silence target-gene expression in a sequence-specific manner. In addition to a Dicer homolog, DCL1, the biogenesis of miRNAs in Arabidopsis requires another protein, HEN1. miRNAs are reduced in abundance and increased in size in hen1(More)
In peer-to-peer (P2P) systems, peers often must interact with unknown or unfamiliar peers without the benefit of trusted third parties or authorities to mediate the interactions. A peer needs reputation mechanisms to incorporate the knowledge of others to decide whether to trust another party in P2P systems. This paper discusses the design of reputation(More)
Methylation on the base or the ribose is prevalent in eukaryotic ribosomal RNAs (rRNAs) and is thought to be crucial for ribosome biogenesis and function. Artificially introduced 2'-O-methyl groups in small interfering RNAs (siRNAs) can stabilize siRNAs in serum without affecting their activities in RNA interference in mammalian cells. Here, we show that(More)