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Gamma-aminobutyric acid (GABA) is an important neurotransmitter that, through the subtype A GABA receptor (GABAAR), induces inhibition in the adult brain. Here we show that an excitatory, rather than inhibitory, GABAergic system exists in airway epithelial cells. Both GABAARs and the GABA synthetic enzyme glutamic acid decarboxylase (GAD) are expressed in(More)
End-to-end reordering of packets on Internet is investigated. Packet streams transferred over the Internet are used to analyze the long-term and short-term trends in reordering. Reorder density (RD) is used to capture comprehensively and concisely the nature of reordering present in a stream. Simpler metrics are derived from RD for monitoring of long-term(More)
OBJECTIVES It is essential to understand the molecular basis of ovarian cancer etiology and tumor development to provide more effective preventive and therapeutic approaches to reduce mortality. Particularly, the molecular targets and pathways involved in early malignant transformation are still not clear. Pro-inflammatory lipids and pathways have been(More)
Knapsack problems are important NP-Complete combinato-rial optimization problems. Although nearly all the classical instances can be solved in pseudo-polynomial time nowadays, yet there are a variety of test problems which are hard to solve for the existing algorithms. In this paper we propose a new approach based upon binary particle swarm optimization(More)
Abrogation of cellular senescence, resulting in immortalization, is a necessary step in the tumorigenic transformation of a cell. Four independent, spontaneously immortalized Li-Fraumeni syndrome (LFS) cell lines were used to analyze the gene expression changes that may have given these cell lines the growth advantage required to become immortal. A cellular(More)
Heterogeneous parallel and distributed computing systems may operate in an environment where certain system performance features degrade due to unpredictable circumstances. Robustness can be defined as the degree to which a system can function correctly in the presence of parameter values different from those assumed. This work develops a model for(More)
A noninvasive screening test would significantly facilitate early detection of epithelial ovarian cancer. This study used a combination of high-throughput selection and array-based serologic detection of many antigens indicative of the presence of cancer, thereby using the immune system as a biosensor. This high-throughput selection involved biopanning of(More)
Echinococcus granulosus, the etiologic agent of cystic echinococcosis in humans and other animal hosts, is distributed worldwide. Echinococcosis is an increasing public health and socioeconomic concern. The present work evaluated whether or not a superabsorbent polymer (SAP) could enhance the damage efficacy of high-intensity focused ultrasound (HIFU) on(More)
Currently, no effective tool exists for screening or early diagnosis of head and neck squamous cell carcinoma (HNSCC). Here, we describe an approach for cancer detection based on analysis of patterns of serum immunoreactivity against a panel of biomarkers selected using microarray-based serologic profiling and specialized bioinformatics. We biopanned phage(More)