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Persistence of side population cells with high drug efflux capacity in pancreatic cancer.
TLDR
SP cells with inherently high resistance to chemotherapeutic agents do exist in pancreatic cancers, which may be candidate cancer stem cells contributing to the relapse of the tumor.
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METTL3-mediated m6A mRNA modification of FBXW7 suppresses lung adenocarcinoma
TLDR
It is revealed that METTL3 positively regulates FBXW7 expression and confirm the tumor-suppressive role of m 6 A-modified FBxW7, thus providing insight into its epigenetic regulatory mechanisms in LUAD initiation and development.
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Berberine Inhibits Metastasis of Nasopharyngeal Carcinoma 5-8F Cells by Targeting Rho Kinase-mediated Ezrin Phosphorylation at Threonine 567*
TLDR
Berberine reduces motility and invasion of cells and inhibits tumor metastasis and the reduction of Rho kinase-mediated Ezrin phosphorylation mediated by berberine may be a novel anti-metastatic pathway in NPC 5-8F cells.
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β-Elemene induces apoptosis in human renal-cell carcinoma 786-0 cells through inhibition of MAPK/ERK and PI3K/Akt/ mTOR signalling pathways.
TLDR
The data provide first evidence that β-elemene can inhibit the proliferation of RCC 786- 0 cells by inducing apoptosis as well as protective autophagy, and combined treatment of β- elemene with autophile inhibitors 3-methyladenine or chlorochine significantly enhanced the anti-tumor effects.
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Autophagy protein LC3 regulates the fibrosis of hypertrophic scar by controlling Bcl-xL in dermal fibroblasts
TLDR
Transmission electron microscopy and immunostaining data showed that LC3-positive cells and autophagosomes in HS/HSFs were more intensive relative to those in NS/NSFs groups, and Immunofluorescence results showed that instead of inhibiting α-SMA protein expression, shLC3 could change its architecture arrangement in HSFs, which obviously improved the appearance and architecture of the rabbit ear scar.
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Overexpression of TROP2 promotes proliferation and invasion of ovarian cancer cells
TLDR
It is suggested that the expression of TROP2 was related to cellular proliferation, migration and invasion and may have a crucial role in tumorigenesis and tumor progression by disturbing the Bax/Bcl-2 balance in ovarian cancer.
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Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells
TLDR
Baicalein reduces the migration and invasiveness of A431 cells through the inhibition of Ezrin expression, which leads to the suppression of tumor metastasis.
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MiR-3174 promotes proliferation and inhibits apoptosis by targeting FOXO1 in hepatocellular carcinoma.
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Targeting EGFL7 expression through RNA interference suppresses renal cell carcinoma growth by inhibiting angiogenesis.
TLDR
Analysis of data from a co-culture system in vitro and a xenograft model in vivo suggests that EGFL7 has an important function in the growth of RCC by facilitating angiogenesis.
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PRMT5 Promotes Aerobic Glycolysis and Invasion of Breast Cancer Cells by Regulating the LXRα/NF-κBp65 Pathway
TLDR
Down-regulating the expression of PRMT5 could counteract the promotion of down-regulation of LXRα on proliferation, invasion and glycolysis of BCCs, and the nude mouse tumorigenesis test revealed thatPRMT5 induced tumor on nude mice by mediating LXR α/NF-κBp65.
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