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Neuronal activity shapes the dendritic arbour; however, most of the molecular players in this process remain to be identified. We observed that depolarization-induced neuronal activity causes an increase in the phosphorylation of glycogen synthase kinase-3 (GSK-3)α/β on Ser21/9 in cerebellar granule neurons. Using several approaches, including gene(More)
Glycogen synthase kinase-3 (GSK-3) plays a critical role in neuronal apoptosis. The two mammalian isoforms of the kinase, GSK-3α and GSK-3β, are inhibited by phosphorylation at Ser-21 and Ser-9, respectively. Depolarization, which is vital for neuronal survival, causes both an increase in Ser-21/9 phosphorylation and an inhibition of GSK-3α/β. However, the(More)
The antibody gene mutator activation-induced cytidine deaminase (AID) promiscuously damages oncogenes, leading to chromosomal translocations and tumorigenesis. Why nonimmunoglobulin loci are susceptible to AID activity is unknown. Here, we study AID-mediated lesions in the context of nuclear architecture and the B cell regulome. We show that AID targets are(More)
Gastric cancer remains the main cause of cancer death all around the world, and upregulated activation of the nonreceptor tyrosine kinase c-SRC (SRC) is a key player in the development. In this study, we found that expression of Src is also increased in clinical gastric cancer samples, with the protein level increased more significantly than that at the RNA(More)
Recent advances in bioinformatics promote drug-design methods that aim to reduce side-effects. Efficient computational methods are required to identify the optimal enzyme-combination (i.e., drug targets) whose inhibition, will achieve the required effect of eliminating a given target set of compounds, while incurring minimal side-effects. We formulate the(More)
— In this paper, we propose a new algorithm for jointly processing a set of Hermitian matrices. It is called structured joint congruence (STJOCO) transformation. Instead of simultaneously diagonalizing a set of matrices, the STJOCO transformation finds a non-singular matrix which jointly minimizes the squared magnitude of the off-diagonal elements in the(More)
In cerebellar granule neurons, a BH3-only Bcl-2 family member, death protein 5/harakiri, is up-regulated in a JNK-dependent manner during apoptosis induced by potassium deprivation. However, it is not clear whether c-Jun is directly involved in the induction of dp5. Here, we showed that the up-regulation of dp5, but not fas ligand and bim, after potassium(More)
— Regularized block diagonalization (RBD) is a new linear precoding technique for the multi-antenna broadcast channel and has a significantly improved sum rate and diversity order compared to all previously proposed linear precoding techniques. We consider a limited feedback system with RBD precoding, in which each receiver has perfect channel state(More)
—A new transmission strategy that consists of a spatial scheduling algorithm and two precoding algorithms is developed for multicarrier multiuser (MU) multiple-input–multiple-output (MIMO) systems. The scheduling algorithm, which is called efficient multicarrier ProSched (EMC-ProSched), adopts a novel and effective scheduling metric for each user and can(More)