Learn More
Neuronal activity shapes the dendritic arbour; however, most of the molecular players in this process remain to be identified. We observed that depolarization-induced neuronal activity causes an increase in the phosphorylation of glycogen synthase kinase-3 (GSK-3)α/β on Ser21/9 in cerebellar granule neurons. Using several approaches, including gene(More)
Recent advances in bioinformatics promote drug-design methods that aim to reduce side-effects. Efficient computational methods are required to identify the optimal enzyme-combination (i.e., drug targets) whose inhibition, will achieve the required effect of eliminating a given target set of compounds, while incurring minimal side-effects. We formulate the(More)
— In this paper, we propose a new algorithm for jointly processing a set of Hermitian matrices. It is called structured joint congruence (STJOCO) transformation. Instead of simultaneously diagonalizing a set of matrices, the STJOCO transformation finds a non-singular matrix which jointly minimizes the squared magnitude of the off-diagonal elements in the(More)
The antibody gene mutator activation-induced cytidine deaminase (AID) promiscuously damages oncogenes, leading to chromosomal translocations and tumorigenesis. Why nonimmunoglobulin loci are susceptible to AID activity is unknown. Here, we study AID-mediated lesions in the context of nuclear architecture and the B cell regulome. We show that AID targets are(More)
Glycogen synthase kinase-3 (GSK-3) plays a critical role in neuronal apoptosis. The two mammalian isoforms of the kinase, GSK-3α and GSK-3β, are inhibited by phosphorylation at Ser-21 and Ser-9, respectively. Depolarization, which is vital for neuronal survival, causes both an increase in Ser-21/9 phosphorylation and an inhibition of GSK-3α/β. However, the(More)
In cerebellar granule neurons, a BH3-only Bcl-2 family member, death protein 5/harakiri, is up-regulated in a JNK-dependent manner during apoptosis induced by potassium deprivation. However, it is not clear whether c-Jun is directly involved in the induction of dp5. Here, we showed that the up-regulation of dp5, but not fas ligand and bim, after potassium(More)
—A new transmission strategy that consists of a spatial scheduling algorithm and two precoding algorithms is developed for multicarrier multiuser (MU) multiple-input–multiple-output (MIMO) systems. The scheduling algorithm, which is called efficient multicarrier ProSched (EMC-ProSched), adopts a novel and effective scheduling metric for each user and can(More)
This thesis describes Cilk, a parallel multithreaded language for programming contemporary shared memory multiprocessors (SMP's). Cilk is a simple extension of C which provides constructs for parallel control and synchronization. Cilk imposes very low overheads | the typical cost of spawning a parallel thread is only between 2 and 6 times the cost of a C(More)