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BACKGROUND The standard treatment for patients with multiple myeloma who are not candidates for high-dose therapy is melphalan and prednisone. This phase 3 study compared the use of melphalan and prednisone with or without bortezomib in previously untreated patients with multiple myeloma who were ineligible for high-dose therapy. METHODS We randomly(More)
The authors propose a topological analysis of large urban street networks based on a computational and functional graph representation. This representation gives a functional view in which vertices represent named streets and edges represent street intersections. A range of graph measures, including street connectivity, average path length, and clustering(More)
OBJECTIVES This study sought to assess the prevalence of the metabolic syndrome (MetS) and its association with cardiovascular disease (CVD) in elderly Chinese people. BACKGROUND The information available about the prevalence of MetS based on the National Cholesterol Education Program (NCEP) and the International Diabetes Federation (IDF) in China is(More)
We provide a research agenda for the International Cartographic Association’s Commission on Visualization and Virtual Environment working group on Cognitive and Usability Issues in Geovisualization. Developments in hardware and software have led to (and will continue to stimulate) novel methods for visualizing geospatial data. It is our belief that these(More)
We investigate multiple-input multiple-output (MIMO) eigenmode transmission using statistical channel state information at the transmitter. We consider a general jointly correlated MIMO channel model, which does not require separable spatial correlations at the transmitter and receiver. For this model, we first derive a closed-form tight upper bound for the(More)
Recently, privacy preserving data publishing has received a lot of attention in both research and applications. Most of the previous studies, however, focus on static data sets. In this paper, we study an emerging problem of <i>continuous privacy preserving publishing of data streams</i> which cannot be solved by any straightforward extensions of the(More)
PURPOSE The purpose of this study was to confirm overall survival (OS) and other clinical benefits with bortezomib, melphalan, and prednisone (VMP) versus melphalan and prednisone (MP) in the phase III VISTA (Velcade as Initial Standard Therapy in Multiple Myeloma) trial after prolonged follow-up, and evaluate the impact of subsequent therapies. PATIENTS(More)
This paper examines location-based services (LBS) from a broad perspective involving deWnitions, characteristics, and application prospects. We present an overview of LBS modeling regarding users, locations, contexts and data. The LBS modeling endeavors are cross-examined with a research agenda of geographic information science. Some core research themes(More)