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Renal agenesis and the absence of enteric neurons in mice lacking GDNF
GLIAL-CELL-LINE-DERIVED neurotrophic factor (GDNF)1 is a potent survival factor for dopaminergic neurons and motor neurons in culture1,2. It also protects these neurons from degeneration in vitro3–9,Expand
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Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019
Abstract Background The novel coronavirus SARS-CoV-2 is a newly emerging virus. The antibody response in infected patient remains largely unknown, and the clinical values of antibody testing have notExpand
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Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019
Summary Background The novel coronavirus SARS-CoV-2 is a newly emerging virus. The antibody response in infected patient remains largely unknown, and the clinical values of antibody testing have notExpand
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Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease
The developmental biology of the dopamine (DA) system may hold important clues to its reconstruction. We hypothesized that factors highly expressed during nigrostriatal development and re-expressedExpand
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Silver nanoparticle exposure attenuates the viability of rat cerebellum granule cells through apoptosis coupled to oxidative stress.
The impact of silver nanoparticles (AgNPs) on the central nervous system is a topic with mounting interest and concern and the facts remain elusive. In the current study, the neurotoxicity ofExpand
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Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer.
Somatic missense mutations in the substrate-binding pocket of the E3 ubiquitin ligase adaptor SPOP are present in up to 15% of human prostate adenocarcinomas, but are rare in other malignancies,Expand
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The potential of self-assembled, pH-responsive nanoparticles of mPEGylated peptide dendron-doxorubicin conjugates for cancer therapy.
Nanoparticles, such as dendritic polymers, are currently investigated as excellent candidates for drug delivery vehicles. In this study, we report the preparation and characterization of mPEGylatedExpand
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Biochemical Control of CARM1 Enzymatic Activity by Phosphorylation*
Coactivator-associated arginine methyltransferase 1 (CARM1) is a dual functional coregulator that facilitates transcription initiation by methylation of Arg17 and Arg26 of histone H3 and alsoExpand
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Locus coeruleus cellular and molecular pathology during the progression of Alzheimer’s disease
A major feature of Alzheimer’s disease (AD) is the loss of noradrenergic locus coeruleus (LC) projection neurons that mediate attention, memory, and arousal. However, the extent to which the LCExpand
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Alpha7 nicotinic receptor up-regulation in cholinergic basal forebrain neurons in Alzheimer disease.
BACKGROUND Dysfunction of basocortical cholinergic projection neurons of the nucleus basalis (NB) correlates with cognitive deficits in Alzheimer disease (AD). Nucleus basalis neurons receiveExpand
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