Bin Guan

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Angiotensin-converting enzyme 2 protects from severe acute lung failure

Yumiko Imai, Keiji Kuba, +15 authors Josef M. Penninger
Nature
2005

Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury, is a devastating clinical syndrome with a high mortality rate (30–60%) (refs 1–3). Predisposing factors for ARDS… (More)

Analysis of Atlantic SST Variability Factoring Interbasin Links and the Secular Trend : Clarified Structure of the Atlantic Multidecadal Oscillation

Bin Guan, Sumant Nigam
2009

Atlantic SST variability in the twentieth century is analyzed factoring the influence of natural SST variability in the Pacific basin and the secular change in global SSTs. The tropical and northern… (More)

A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury

Keiji Kuba, Yumiko Imai, +21 authors Josef M. Penninger
Nature Medicine
2005

During several months of 2003, a newly identified illness termed severe acute respiratory syndrome (SARS) spread rapidly through the world. A new coronavirus (SARS-CoV) was identified as the SARS… (More)

Mutation and loss of expression of ARID1A in uterine low-grade endometrioid carcinoma.

Bin Guan, T S Mao, +7 authors Ie-Ming Shih
The American journal of surgical pathology
2011

ARID1A is a recently identified tumor suppressor gene that is mutated in approximately 50% of ovarian clear cell and 30% of ovarian endometrioid carcinomas. The mutation is associated with loss of… (More)

ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers.

Bin Guan, Tian-Li Wang, Ie-Ming Shih
Cancer research
2011

ARID1A (BAF250A) promotes the formation of SWI/SNF chromatin remodeling complexes containing BRG1 or BRM. It has emerged as a candidate tumor suppressor based on its frequent mutations in ovarian… (More)

Biochemical and genetic interactions between Drosophila caspases and the proapoptotic genes rpr, hid, and grim.

Zhiyin Song, Bin Guan, +4 authors Hermann Steller
Molecular and cellular biology
2000

In Drosophila melanogaster, the induction of apoptosis requires three closely linked genes, reaper (rpr), head involution defective (hid), and grim. The products of these genes induce apoptosis by… (More)

Roles of deletion of Arid1a, a tumor suppressor, in mouse ovarian tumorigenesis.

Bin Guan, Yohan Suryo Rahmanto, +4 authors Ie-Ming Shih
Journal of the National Cancer Institute
2014

The chromatin remodeling gene, ARID1A, has been implied as a tumor suppressor, and its somatic inactivating mutations occur in a wide variety of human cancers, most frequently in ovarian and uterine… (More)

Pacific Sea Surface Temperatures in the Twentieth Century : An Evolution-Centric Analysis of Variability and Trend

Bin Guan, Sumant Nigam
2008

A consistent analysis of natural variability and secular trend in Pacific SSTs in the twentieth century is presented. By focusing on spatial and temporal recurrence, but without imposition of… (More)

Analysis of DNA copy number alterations in ovarian serous tumors identifies new molecular genetic changes in low-grade and high-grade carcinomas.

Kuan-Ting Kuo, Bin Guan, +7 authors Tian-Li Wang
Cancer research
2009

Ovarian serous carcinoma, the most common and lethal type of ovarian cancer, is thought to develop from two distinct molecular pathways. High-grade (HG) serous carcinomas contain frequent TP53… (More)

NKX3.1 is regulated by protein kinase CK2 in prostate tumor cells.

Xiang Shu Li, Bin Guan, Sam Maghami, Charles J. Bieberich
Molecular and cellular biology
2006

Diminished expression of NKX3.1 is associated with prostate cancer progression in humans, and in mice, loss of nkx3.1 leads to epithelial cell proliferation and altered gene expression patterns. The… (More)

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