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The Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism essential for embryonic development in mammals. Mutations in the human JAGGED1 ( JAG1 ) gene, which encodes a ligand for the Notch family of transmembrane receptors, cause the autosomal dominant disorder Alagille syndrome. We have examined the in vivo role of the(More)
  • Jay Y Li, David C Mauer, Aziz Alimov, Nina Baranchuk, Alex Butler, Bin Chang +12 others
  • 2014
We examine interactions between investment and financing decisions in a dynamic model where the firm may alter the mix of debt and equity financing and may exercise a growth option. The key feature of the model is that the growth option arrives randomly and can be lost due to competition or technological obsolescence. We find that the firm will typically(More)
Traffic routing plays a critical role in determining the performance of a wireless mesh network. Recent research results usually fall into two ends of the spectrum. On one end are the heuristic routing algorithms, which are highly adap-tive to the dynamic environments of wireless networks yet lack the analytical properties of how well the network performs(More)
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