Bimal Chatterjee

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We describe a new mouse frameshift mutation (Pax2(1Neu)) with a 1-bp insertion in the Pax2 gene. This mutation is identical to a previously described mutation in a human family with renal-coloboma syndrome [Sanyanusin, P., McNoe, L. A., Sullivan, M. J., Weaver, R. G. & Eccles, M. R. (1995) Hum. Mol. Genet. 4, 2183-2184]. Heterozygous mutant mice exhibit(More)
Phenotype-based mutagenesis experiments will increase the mouse mutant resource, generating mutations at previously unmarked loci as well as extending the allelic series at known loci. Mapping, molecular characterization, and phenotypic analysis of nine independent Pax6 mutations of the mouse recovered in mutagenesis experiments is presented. Seven(More)
Four independent heterozygous lactate dehydrogenase (LDH) mutations with approximately 60% of wild-type enzyme activity in whole blood have been recovered. The mutant line Ldh1 a2Neu proved to be homozygous lethal, whereas for the three lines Ldh1 a7Neu, Ldh1 a11Neu, and Ldh1 a12Neu homozygous mutants with about 20% residual activity occurred in the progeny(More)
Four electrophoretic and/or enzyme-activity variants of murine LDH-A subunit (Ldh1 a-m1Neu, Ldh1 a-m5Neu, Ldh1 a-m6Neu, Ldh1 a-m9Neu), induced by procarbazine hydrochloride or ethylnitrosourea (ENU), were analyzed at the DNA level. The exons of the Ldh1 gene from homozygous mutants were amplified by PCR and sequenced. Three mutations resulted from(More)
The amino acid and carbohydrate analysis of scyllin, a low molecular weight lectin purified from Scylla serrata (edible crab) haemolymph reveal that scyllin is rich in acidic and neutral amino acids and contains high amount of mannose. UV absorption of scyllin is perturbed by DMSO at 272 nm showing the presence of tryptophan molecule in scyllin exposed and(More)
The homozygous mouse mutant aphakia (ak) has been characterized by bilaterally aphakic eyes without a pupil [Varnum DS, Stevens, LC (1968): J Hered 59:147-150]. The mutation was mapped to chromosome 19 [Varnum DS, Stevens, LC (1975): Mouse News Lett 53:35]. Our linkage studies yielded a precise localization of the ak gene 0.6 +/- 0.3 cM proximal to the(More)
Phenotype-based mutagenesis experiments will increase the mouse mutant resource, generating mutations at previously unmarked loci as well as extending the allelic series at known loci. Mapping, molecular characterization, and phenotypic analysis of nine independent Pax6 mutations of the mouse recovered in mutagenesis experiments is presented. Seven(More)
The objective of this study was to extract and evaluate key catchment characteristics explaining the main variation in properties of dissolved natural organic matter (DNOM) in surface waters draining each catchment. A number of classical and sophisticated DNOM characterisation methodologies were used for this purpose. The explanatory capability of site(More)
The cDNA sequence of the beta B2-cry was determined from hamster (Mesocricetus auratus) and compared to the corresponding genes of bovine, frog, chicken, human, mouse and rat. Multispecies comparison demonstrated high homology between the hamster, rat and mouse gene, but larger distances to man, bovine, chicken and frog. There is striking identity within a(More)
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