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OBJECTIVE Ferumoxytol, an ultrasmall superparamagnetic iron oxide particle, has been suggested as a potential alternative MRI contrast agent in patients with renal failure. We compared ferumoxytol to gadoteridol enhancement on T1- and T2-weighted MRI in CNS disorders to explore its diagnostic utility. SUBJECTS AND METHODS Data were collected from three(More)
Ferrets were tested for their ability to detect temporal gaps in noise before and after bilateral lesions of the primary auditory cortex. Thresholds for gap detection were determined first for normal animals with band-pass noises at various center frequencies (0.5 to 32 kHz) and at 8 kHz with various sound pressure levels (-10-70 dB). Gap-detection ability(More)
2-Deoxy[14C]glucose (2-DG) uptake was examined in pentobarbital-anesthetized rats that 3 days to 2 years earlier had sustained large posterior neocortical ablations. At 2 weeks postoperatively 2-DG uptake was pronounced in those thalamic nuclei with cortical projection zones included in the ablated region. At shorter postoperative intervals (3 to 4 days)(More)
The 2-deoxyglucose (2-DG) technique was used to determine the effects of pattern and diffuse light stimulation on glucose metabolism with hooded rats. Rats placed in a stimulation chamber covered with horizontal and vertical square wave gratings while wearing goggles with one of three pairings of light-occluding, diffusing, or clear lenses, allowed the(More)
Lesions of the superior olivary complex of the adult ferret were made by pressure injection of kainic acid (5 nM/microliters in Locke's solution) through a glass micropipette inserted into the lower brain-stem. Small injections of kainic acid (1.5 microliters) produced a localized loss of nerve cells in the superior olivary complex in the vicinity of the(More)
The 2-deoxyglucose (2-DG) technique was used to assess rat visual system metabolic activity after topical eye application of atropine sulfate. After one pupil had been dilated with atropine, the alert and freely moving rats were surrounded by a montage of horizontal and vertical, black and white, square wave gratings of varying spatial frequencies during(More)
Thirty-five unstable dorsally displaced fractures of the distal radius in 34 patients (mean age 39) were studied; 28 fractures were intra-articular. All fractures had open reduction and fixation, through a dorsal approach, with mini-fragment plates placed between the first and second dorsal tendon compartments and deep to the fourth compartment. A congruous(More)
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