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BACKGROUND Treatment of in-stent restenosis presents a critical limitation of intracoronary stent implantation. Ionizing radiation has been shown to decrease neointimal formation within stents in animal models and in initial clinical trials. We studied the effects of intracoronary gamma-radiation therapy versus placebo on the clinical and angiographic(More)
BACKGROUND The efficacy of fibrinolytic therapy is limited by the small surface area of the clot that is available for the binding of the thrombolytic agent, such as tissue-type plasminogen activator (t-PA). We hypothesized that exposure of the clot to ultrasound during thrombolytic treatment could enhance lysis through perturbation of the thrombus, which(More)
  • B G Bass
  • 1975
of the action potential i n cat papillary muscle. Am. J. Physiol. Z%(6) : 17 17-l 724. 1975.-Membrane recovery (electrical restitution) following an action potential (AP) was studied in isolated, electrically driven cat papillary muscle by interpolation of test extrasystoles at various delays in the interval between two AP's (recorded with glass(More)
BACKGROUND The Washington Radiation for In-Stent Restenosis Trial is a double-blinded randomized study evaluating the effects of intracoronary radiation therapy (IRT) in patients with in-stent restenosis (ISR). METHODS AND RESULTS One hundred thirty patients with ISR (100 native coronary and 30 vein grafts) underwent percutaneous transluminal coronary(More)
1. The mechanical and electrophysiological effects of Sr were evaluated and compared to those of Ca in isolated, electrically driven toad ventricular muscle strips. The effects of Ca and Sr were compared at concentrations from control (2 mM) to 10 mM either by substitution of Sr for Ca at equimolar concentration, or by maintenance of a constant total Ca(More)
  • B G Bass
  • 1999
Cardiovascular brachytherapy, the use of high intensity radiation to inhibit the growth of neointimal tissue after coronary revascularization by either balloon angioplasty or other methods is being tested in a number of clinical trials to assess the efficacy of the treatment. This new use of radiation to aleviate the suffering of individuals with coronary(More)
To study the effect of histamine (HA) on brain blood flow and capillary permeability, bilateral parietal craniectomies were made in cats anesthetized with nitrous oxide and ketamine. The dura was removed and solutions of HA in mock cerebrospinal fluid (CSF) in varying concentrations ranging from 10(-5) M to 10(-1) M were irrigated continuously onto the(More)
  • B G Bass
  • 1975
Contractility during relaxation of isometric tension was studied in isolated, electrically driven cat papillary muscle by interpolation of test extrasystoles, all of whichpartially fused with their antecedent (control) contractions, were separated by computer from the fused contractions and then analyzed. The time course of the restitutionof contractility(More)