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Acute tubulointerstitial nephritis (TIN) is a frequent cause of acute renal failure, characterised by the presence of inflammatory cell infiltrate in the interstitium of the kidney. Immuno-allergic reaction to certain medications, mainly non-steroidal anti-inflammatory drugs and antibiotics are by far the most important etiology for TIN today, but other(More)
BACKGROUND AND OBJECTIVES Steroid-resistant nephrotic syndrome is a rare kidney disease involving either immune-mediated or genetic alterations of podocyte structure and function. The rare nature, heterogeneity, and slow evolution of the disorder are major obstacles to systematic genotype-phenotype, intervention, and outcome studies, hampering the(More)
BACKGROUND Mass urinary screening is a useful tool to identify children with asymptomatic progressive renal diseases. A dipstick urinalysis screening was conducted to detect such prevalence and to set up a more effective screening program for children. PATIENTS AND METHODS A cross sectional study was carried out in seven nurseries and primary schools in(More)
Congenital nephrotic syndrome of the Finnish type (CNF) is due to NPHS1 mutation and is responsible for a variety of urinary protein losses. We report the case of a 4-month-old girl with a particularly severe form (proteinuria approximately 150 g/l) of CNF. She developed severe non-regenerative anaemia requiring bi-monthly blood transfusions despite daily(More)
Idiopathic nephrotic syndrome (INS) is defined as massive proteinuria and hypoalbuminemia associated with dyslipidemia and generalized oedema in most cases. It is thought to be due to a plasma factor of immunologic origin. Most cases are steroid responsive. However, a considerable proportion of children run a steroid dependent course. Calcineurin inhibitors(More)
A 16-month old female child presented with a 1-day history of urinary retention. As for the past medical history, the mother noted chronic constipation since the age of 2 months, which was treated by laxatives. On presentation the patient was alert and active without signs of peripheral edema. Upon admission she had normal vital signs, a blood pressure of(More)
Dear Sirs, We have previously shown that pediatric patients with nephrotic syndrome have a high serological response after 23valent pneumococcal vaccination [1]. The response was not different in those who received the vaccine in remission without steroids and those who received the vaccine while having nephrotic proteinuria and high dose steroids. However,(More)
1. Podar K, Catley LP, Tai YT, et al. GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment. Blood. 2004;103:3474-3479. 2. Hurwitz H, Dowlati A, Savage S, et al. Safety, tolerability and pharmacokinetics of oral administration of GW786034 in pts with solid tumors(More)
blockers is also known to cause chylous ascites with high levels of triglycerides (5). In the present case, the cause was high doses of long-chain fatty acids (supported by the fact that the chyloperitoneum disappeared when those agents were stopped and recurred when they were restarted because of the poor nutrition status of the patient). To our knowledge,(More)