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A highly sensitive, rapid assay method has been developed and validated for the estimation of JI-101 in human plasma and urine using LC-MS/MS-ESI in the positive-ion mode. The assay procedure(More)
Literature data on the clinical pharmacokinetics of various VEGFR-2 inhibitors along with in vitro potency data were correlated and a linear relationship was established in spite of limited data set.(More)
e15077 Background: The effects of JI-101 on the pharmacokinetics (PK) of everolimus and vice versa were investigated in an open-label single sequence cross over study. This was the first clinical(More)
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