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A Preformulation Strategy for the Selection of Penetration Enhancers for a Transungual Formulation
The proposed preformulation strategy helps to select appropriate enhancers for optimum topical delivery and paves way towards an efficient topical formulation for passive transungual drug delivery.
Lateral Drug Diffusion in Human Nails
Profound lateral diffusion of CPO was demonstrated and shown to reduce the in vitro passive transungual drug permeation and prolong the lag-time in human toenails, implying that during passive in vitro transungUAL permeation experiments, the peripheral nail around the area of drug application has to be kept to a minimum, in order to get reliable data which mimics the in vivo situation.
A NOVEL TRANSUNGUAL FORMULATION (NAIL PATCH) FOR DELIVERY OF CICLOPIROX OLAMINE INTO THE NAIL AND THE NAIL FOLDS
The in vitro release profile shows greater than 80% of drug release within 2 h indicating that the drug release is not the rate limiting step in drug delivery, and patch showed significant increase in epidermal accumulation and transungual permeation flux compared to the commercial formulation.