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Epstein-Barr virus is known to cause nasopharyngeal carcinoma. Although oral cavity is located close to the nasal pharynx, the pathogenetic role of Epstein-Barr virus (EBV) in oral cancers is unclear. This molecular epidemiology study uses EBV genomic microarray (EBV-chip) to simultaneously detect the prevalent rate and viral gene expression patterns in 57(More)
Intraocular pressure (IOP) in light-dark entrained rabbits changes in a circadian pattern. Previous studies indicate that signals for the circadian IOP elevation in the early dark phase come from the central nervous system (CNS) via the ocular sympathetic nerves. Its neural circuitry in the CNS was totally unclear. In the present study, the role of the(More)
Previous work demonstrated that NAD(P)H:quinone oxidoreductase 1 (NQO1) metabolized the heat shock protein 90 (Hsp90) inhibitor 17-(allylamino)-17-demethoxygeldanamycin (17AAG) to the corresponding hydroquinone (17AAGH₂). The formation of 17AAGH₂ by NQO1 results in a molecule that binds with greater affinity to Hsp90 compared with the parent quinone. 17AAG(More)
Among eight human bladder cancer cell lines we examined, only T24 cells were resistant to the growth inhibition effect of genistein, an isoflavone and potent anticancer drug. Since the T24 cell line was the only cell line known to overexpress oncogenic H-Ras(val 12), we investigated the role of H-Ras(val 12) in mediating drug resistance. Herein, we(More)
There are hundreds of viruses that infect different human organs and cause diseases. Some fatal emerging viral infections have become serious public health issues worldwide. Early diagnosis and subsequent treatment are therefore essential for fighting viral infections. Current diagnostic techniques frequently employ polymerase chain reaction (PCR)-based(More)
In light-dark entrained rabbits, the intraocular pressure (IOP) increases around the onset of dark due to the increased activities of ocular sympathetic nerves. This circadian elevation of IOP can be eliminated by exposing the rabbits to constant white light in the early subjective dark phase. The spectral effectiveness of light causing the reduction in IOP(More)
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