Bich Hai Ho

Learn More
BACKGROUND Nucleosome, the fundamental unit of chromatin, is formed by wrapping nearly 147bp of DNA around an octamer of histone proteins. This histone core has many variants that are different from each other by their biochemical compositions as well as biological functions. Although the deposition of histone variants onto chromatin has been implicated in(More)
Histone proteins are subject to various posttranslational modifications (PTMs). Elucidating their functional relationships is crucial toward understanding many biological processes. Bayesian network (BN)-based approaches have shown the advantage of revealing causal relationships, rather than simple cooccurrences, of PTMs. Previous works employing BNs to(More)
Eukaryotic gene transcription is a complex process, which requires the orchestrated recruitment of a large number of proteins, such as sequence-specific DNA binding factors, chromatin remodelers and modifiers, and general transcription machinery, to regulatory regions. Previous works have shown that these regulatory proteins favor specific organizational(More)
Nucleosome, a nucleoprotein structure formed by coiling 147 bp of DNA around an octamer of histone proteins, is the fundamental repeating unit of eukary-otic chromatin. By regulating the access of biological machineries to underlying cis-regulatory elements, its mobility has been implicated in many important cellular processes. Although it has been known(More)
  • 1