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Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells.
It is shown for the first time that PD is a potent anticancer agent that can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction. Expand
Effects of polyphyllin D, a steroidal saponin in Paris Polyphylla, in growth inhibition of human breast cancer cells and in xenograft
In vivo study demonstrated that daily administration of polyphyllin D through intravenous injection for ten days in nude mice bearing MCF-7 cells effectively reduced tumor growth for 50% in terms of tumor weight and size, given no significant toxicity in heart and liver to the host. Expand
Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells.
Observations suggest that polyphyllin D is a potent anti-cancer agent that bypasses MDR and elicits apoptosis via mitochondrial injury. Expand
First Total Synthesis of an Exceptionally Potent Antitumor Saponin, OSW-1.
OSW-1 (1), an acylated disaccharide cholestane saponin from Ornithogalum saudersiae with exceptionally potent antitumor activity, was first synthesized from commercially availableExpand
Synthesis of mangiferin, isomangiferin, and homomangiferin.
Mangiferin, isomangiferin, and homomangiferin, the xanthone C-glycosides with a wide spectrum of pharmacological effects, were synthesized concisely, featuring a C-glycosylation of a xantheneExpand
Three new homoisoflavanone glycosides from the bulbs of Ornithogalum caudatum.
Phytochemical examination of Ornithogalum caudatum led to the isolation of three new homoisoflavanone glycosides. Their structures were elucidated, on the basis of the spectroscopic data and chemicalExpand
Exploration of the correlation between the structure, hemolytic activity, and cytotoxicity of steroid saponins.
The results suggest that steroid saponins execute hemolytic and cytotoxic activity in different mechanisms, and encourage to develop steroid sap onins into potent antitumor agents devoid of the detrimental effect of hemolysis. Expand
Resveratrol glucuronides as the metabolites of resveratrol in humans: characterization, synthesis, and anti-HIV activity.
It is found that resveratrol was metabolized in humans into two metabolites, which were characterized as resver atrol-3-O- and 4'-O-glucuronides, which have implications for future development of resverAtrol and/or its derivatives as a chemotherapeutic agent. Expand
Polyphyllin D induces apoptosis in human erythrocytes through Ca2+ rise and membrane permeabilization
The toxicity of PD in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis of human erythrocytes are reported for the first time. Expand
Five new Ocotillone-type saponins from Gynostemma pentaphyllum.
Five new ocotillone-type saponins, gynosides A-E (1-5), along with 10 known dammarane-type saponins, were isolated from the aerial parts of Gynostemma pentaphyllum. The structures of these newExpand