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A Hormone-Dependent Module Regulating Energy Balance
A hormone-regulated pathway that functions in parallel with the nutrient-sensing SIRT1 pathway to maintain energy balance is revealed, reflecting FOXO-dependent increases in lipolysis that deplete triglyceride stores. Expand
The insulin-regulated CREB coactivator TORC promotes stress resistance in Drosophila.
It is shown that starvation also triggers TORC activation in Drosophila, where it maintains energy balance through induction of CREB target genes in the brain to maintain energy balance. Expand
Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance
- Run Shen, Biao Wang, M. Giribaldi, J. Ayres, John B. Thomas, M. Montminy
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 20 May 2016
The results reveal a previously unidentified tolerance defense strategy involving a brain–gut pathway that maintains homeostasis through its effects on epithelial integrity in Drosophila. Expand
Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits.
It is shown that BAT-specific liver kinase b1 knockout mice exhibited impaired BAT mitochondrial respiration and thermogenesis but reduced adiposity and liver triglyceride accumulation under high-fat-diet feeding at room temperature, and that ETC proteome imbalance in BAT regulates systemic metabolism independently of thermogenesis. Expand
Deletion of the serotonin 2c receptor from transgenic mice overexpressing leptin does not affect their lipodystrophy but exacerbates their diet-induced obesity.
On a chow diet, leptin action is independent of 5HT2c receptors whereas on a high fat diet 5HT1c receptors are required for the attenuation of obesity, demonstrating that perturbations of the 5 HT2c receptor and leptin pathways negatively impact on POMC expression. Expand
Adipocyte Liver Kinase b1 Suppresses Beige Adipocyte Renaissance Through Class IIa Histone Deacetylase 4
It is shown that beige adipocytes formed postnatally in subcutaneous inguinal white adipose tissue lost thermogenic gene expression and multilocular morphology at the adult stage, but cold restored their beiging characteristics, a phenomenon termed beige lipid renaissance. Expand
TFEB-driven endocytosis coordinates MTORC1 signaling and autophagy
This study characterizes TFEB-mediated endocytosis as a critical process leading to activation of MTORC1 and autophagic function, thus identifying the importance of the dynamic endolysosomal system in cellular clearance. Expand
Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis
The data indicate that suppressing Sik2 by PKA-mediated phosphorylation is a requisite for SNS-induced UCP1 expression and adaptive thermogenesis in BAT, and targeting Sik2 may present a novel therapeutic strategy to ramp up BAT thermogenic activity in humans. Expand
Towards a Better Understanding of Beige Adipocyte Plasticity
This review summarizes the current knowledge regarding WAT browning, with a special focus on the beige adipocyte plasticity, collectively referring to a bidirectional transition between thermogenic active and latent states in response to environmental changes. Expand
Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling.
- A. Hsu, Qiming Duan, +6 authors Saptarsi M Haldar
- Biology, Medicine
- The Journal of clinical investigation
- 27 February 2020
It is found that SIK1 phosphorylated and stabilized histone deacetylase 7 (HDAC7) protein during cardiac stress, an event that is required for pathologic cardiomyocyte remodeling. Expand