Learn More
Penicillium chrysogenum has been used in producing penicillin and derived β-lactam antibiotics for many years. Although the genome of the mutant strain P. chrysogenum Wisconsin 54-1255 has already been sequenced, the versatility and genetic diversity of this species still needs to be intensively studied. In this study, the genome of the wild-type P.(More)
Juglanthraquinone C (1,5-dihydroxy-9,10-anthraquinone-3-carboxylic acid, JC), a naturally occurring anthraquinone isolated from the stem bark of Juglans mandshurica, shows strong cytotoxicity in various human cancer cells in vitro. Here, we first performed a structure–activity relationship study of six anthraquinone compounds (JC, rhein, emodin,(More)
Seam measuring of complex tight butt joint without misalignment for laser welding is a challenging problem. The allowable seam gap width and misalignment in laser welding process are less than 0.1 mm for thin sheet around 2 mm thickness. Current measuring methods or sensors can not stably and accurately extract 3D seam position and seam gap width, due to(More)
Therapeutic antibodies that target T-cell co-inhibitory molecules display potent antitumor effects in multiple types of cancer. LSECtin is a cell surface lectin of the DC-SIGN family expressed in dendritic cells that inhibits T-cell responses. LSECtin limits T-cell activity in infectious disease, but it has not been studied in cancer. Here we report the(More)
The objective of this paper is to study the effect of efficient importance sampling (EIS) techniques on simulating the distribution-invariant convex risk measures: utility-based shortfall risk measures (USR). We firstly introduce EIS to simulate USR based on nonlinear Generalized Least Squares and demonstrate how to choose a candidate density in the context(More)
Therapeutic antibodies that target T-cell co-inhibitory molecules display potent antitumor effects in multiple types of cancer. LSECtin is a cell surface lectin of the DC-SIGN family expressed in dendritic cells that inhibits T-cell responses. LSECtin limits T-cell activity in infectious disease, but it has not been studied in cancer. Here we report the(More)
A WATM interface card using SOPC technology is presented in this paper. WATM is an extension of fixed ATM networks, and provides users wireless access to broadband services. The SOPC technology, developed by Altera Corporation, consists of a FPGA (field programmable gate array) and a Nios embedded processor. This paper introduces a novel method for design(More)
Juglans mandshurica Maxim (Juglandaceae) is a famous folk medicine for cancer treatment and some natural compounds isolated from it have been studied extensively. Previously we isolated a type of ω-9 polyunsaturated fatty acid (JA) from the bark of J. mandshurica, however little is known about its activity and the underlying mechanisms. In this study, we(More)
Syphilis is a systemic sexually transmitted disease caused by Treponema pallidum ssp. pallidum (TPA). The origin and genetic background of Chinese TPA strains remain unclear. We identified a total of 329 single-nucleotide variants (SNVs) in eight Chinese TPA strains using next-generation sequencing. All of the TPA strains were clustered into three lineages,(More)
DNA polymerase iota (Pol ι) is an error-prone DNA polymerase involved in translesion DNA synthesis (TLS) that contributes to the accumulation of DNA mutations. We recently showed that Pol ι is overexpressed in human esophageal squamous cell cancer (ESCC) tissues which promotes ESCC' progression. The present study was aimed at investigating the molecular(More)