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We study an interesting phenomenon of social influence locality in a large microblogging network, which suggests that users’ behaviors are mainly influenced by close friends in their ego networks. We provide a formal definition for the notion of social influence locality and develop two instantiation functions based on pairwise influence and structural(More)
The development of small molecule chemical probes or therapeutics that target RNA remains a significant challenge despite the great interest in such compounds. The most significant barrier to compound development is defining which chemical and RNA motif spaces interact specifically. Herein, we describe a bioactive small molecule probe that targets expanded(More)
Thermodynamic parameters for GU pairs are important for predicting the secondary structures of RNA and for finding genomic sequences that code for structured RNA. Optical melting curves were measured for 29 RNA duplexes with GU pairs to improve nearest neighbor parameters for predicting stabilities of helixes. The updated model eliminates a prior penalty(More)
Three-way multibranch loops (junctions) are common in RNA secondary structures. Computer algorithms such as RNAstructure and MFOLD do not consider the identity of unpaired nucleotides in multibranch loops when predicting secondary structure. There is limited experimental data, however, to parametrize this aspect of these algorithms. In this study, UV(More)
New approaches have been developed for measuring the rates of electron transfer (ET) across self-assembled molecular monolayers by scanning electrochemical microscopy (SECM). The developed models can be used to independently measure the rates of ET mediated by monolayer-attached redox moieties and direct ET through the film as well as the rate of a(More)
Domain adaptation aims at learning robust classifiers across domains using labeled data from a source domain. Representation learning methods, which project the original features to a new feature space, have been proved to be quite effective for this task. However, these unsupervised methods neglect the domain information of the input and are not(More)
Previously, we reported the synthesis and preliminary characterization of Cu(I/II) complexes of N,N-bis(2-quinilylmethyl)-(l)-methionine (Zahn, S.; Canary, J. W. Science 2000, 288, 1404-7). The chemically oxidized and reduced forms of the complexes gave nearly mirror image circular dichroism (CD) spectra as a result of reorganization of the inner(More)
Research in the last decade suggests the clinical potential of circulating microRNAs in whole blood as biomarkers for cancer detection. However, before applying the identified circulating microRNAs clinically, biospecimen-focused research has to be performed to identify possible preanalytic variables that may significantly affect the levels of circulating(More)
Circulating microRNAs have drawn a great deal of attention as promising novel biomarkers for breast cancer. However, to date, the results are mixed. Here, we performed a three-stage microRNA analysis using plasma samples from breast cancer patients and healthy controls, with efforts taken to address several pitfalls in detection techniques and study design(More)