Bianca Howard

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This is the report of the twenty-ninth of a series of workshops organised by the European Centre for the Validation of Alternative Methods (ECVAM). ECVAM’s main goal, as defined in 1993 by its Scientific Advisory Committee, is to promote the scientific and regulatory acceptance of alternative methods which are of importance to the biosciences and which(More)
Age, sex, and gravidity significantly affect blood values in rhesus monkeys (Macaca mulatta). The objective of the study reported here was to provide clinicians and researchers with complete blood values for clinically normal, domestically reared rhesus monkeys of Indian origin and of different age, sex, and gravidity. Values were obtained from 527 healthy,(More)
1. Plasma levels of beta-hydroxybutyrate (BHB), and acetoacetate (AcAc) have been measured in camels (Camelus dromedarius) and sheep (Ovis aries). The activity of beta-hydroxybutyrate dehydrogenase (BHB-deH2) (E.C. was studied in the rumen epithelium and the liver of these animals. 2. Concentrations of plasma BHB and AcAc in the camel were in(More)
In 2003, under the auspices of the main UK funders of biological and biomedical research, a working group was established with a remit to review potential welfare issues for genetically altered (GA) mice, to summarize current practice, and to recommend contemporary best practice for welfare assessments. The working group has produced a report which makes(More)
1. Four chickens were used in nine successive experiments using a single injection radioisotope dilution technique to study the kinetics of endogenous uric acid and urea metabolism. 2. Starvation lowered uric acid and urea entry rates, but elevated the extent of degradation of these compounds. 3. Urea turnover time and the extent of urea pool degradation(More)
1. A preparation is described for investigating the central nervous control of gastric motility in decerebrate decerebellate sheep.2. The dorsal vagal nucleus has been electrically stimulated in thirty decerebrate sheep, and the effect on the mechanical responses of the different parts of the reticulo-rumen have been determined.3. In the absence of(More)