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Optimizing drug delivery systems using systematic "design of experiments." Part I: fundamental aspects.
TLDR
The article covers the niceties of several important experimental designs, mathematical models, and optimum search techniques using numeric and graphical methods, with special emphasis on computer-based approaches, artificial neural networks, and judicious selection of designs and models.
Self-emulsifying drug delivery systems (SEDDS): formulation development, characterization, and applications.
TLDR
This exhaustive review offers an overview on myriad in vitro, in situ, and ex vivo techniques to assess the absorption and/ or permeation potential of drugs incorporated in the SEDDS in animal and cell line models, and the subsequent absorption pathways followed by them.
Immobilization of α-Amylase Produced by Bacillus circulans GRS 313
A maltooligosaccharide-forming amylase from B circulans GRS 313 was immobilized by entrapment in calcium alginate beads. The immobilized activity was affected by the size of the bead and bead size of
Optimizing drug delivery systems using systematic "design of experiments." Part II: retrospect and prospects.
TLDR
A vast account of various DoE reports on optimization of diverse drug delivery system and processes along with the critical graphical analysis of various designs, input, and response variables have been presented here in a categorical form.
Developing oral drug delivery systems using formulation by design: vital precepts, retrospect and prospects
TLDR
This review article describes the principles of DoE and QbD as applicable to drug delivery development using a more apt expression, that is, ‘formulation by design (FbD)’.
Formulation development and systematic optimization of solid lipid nanoparticles of quercetin for improved brain delivery
TLDR
Solid lipid nanoparticles of quercetin are formulating for intravenous administration in order to improve its permeation across the blood–brain barrier into the CNS, and eventually to improve the therapeutic efficacy of this molecule in Alzheimer's disease.
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