Bhawna Sharma

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BACKGROUND Improved treatment approaches are needed for visceral leishmaniasis. We assessed the efficacy and safety of three potential short-course combination treatments compared with the standard monotherapy in India. METHODS Standard treatment (1 mg/kg amphotericin B infusion on alternate days for 30 days, total dose 15 mg/kg) was compared with three(More)
Artemisinin-based combination therapy (ACT) has been recommended for the treatment of falciparum malaria by the World Health Organization. Though India has already switched to ACT for treating falciparum malaria, there is need to have multiple options of alternative forms of ACT. A randomized trial was conducted to assess the safety and efficacy of the(More)
IMPORTANCE OF THE FIELD The incidence of malignant melanoma is increasing throughout the world and is currently rising faster than any other cancer in men and second only to lung cancer in women. Current strategies focused on systemic therapy for treatment of melanoma have shown no effect on survival. Therefore there is a pressing need for developing novel(More)
CONTEXT Nutritional rickets is usually attributed to vitamin D deficiency. Studies from some tropical countries have postulated low dietary intake of calcium as the cause of nutritional rickets. Both vitamin D and dietary calcium deficiency are highly prevalent in India. Information on their relative contribution in the development of rickets in Indian(More)
Herbal plants or botanical medicines have been used traditionally by herbalist worldwide for the prevention and treatment of liver disease. The plant kingdom plays a major role in the life of human beings and animals. The plant, as one of the important sources, still maintains its original place in the treatment of various diseases, including liver(More)
The incidence of melanoma is rising at an alarming rate and we are still awaiting an effective treatment for this malignancy. In its early stage, melanoma can be cured by surgical removal, but once metastasis has occurred there is no effective treatment. Recent findings have suggested multiple functional implications of CXCL8 and its cognate receptors,(More)
BACKGROUND Stroke is one of the foremost cause of morbidity and mortality, and poses a major socioeconomic problem in young patients, especially in developing countries. MATERIAL/METHODS The present study was conducted in order to analyze the clinical characteristics, stroke types and etiology of stroke in young persons. RESULTS Stroke in young patients(More)
This study analyzes forest change in an area of Nepal that signifies a delicate balance between sustaining the needs and livelihood of a sizable human population dependent on forest products, and an effort to protect important wildlife and other natural resources. The study area, a portion of the Chitwan valley district of Nepal, represents what may be(More)
BACKGROUND & OBJECTIVES In vitro assays are an important tool to assess baseline sensitivity and monitor the drug response of Plasmodium falciparum over time and place and, therefore, can provide background information for the development and evaluation of drug policies. This study was aimed at determining the in vitro sensitivity of P. falciparum isolates(More)
BACKGROUND & OBJECTIVES Structural and/or functional alterations in adrenal glands have been reported in human immunodeficiency virus (HIV) infection. However, no information has been reported from India. Hence a study was undertaken to assess the basal and circadian variations in plasma cortisol, and cortisol response to bolus ACTH in patients with AIDS.(More)