Bhavuk Garg

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MITF (microphthalmia-associated transcription factor) is a frequently amplified lineage-specific oncogene in human melanoma, whose role in intrinsic drug resistance has not been systematically investigated. Utilizing chemical inhibitors for major signaling pathways/cellular processes, we witness MITF as an elicitor of intrinsic drug resistance. To search(More)
BACKGROUND Activity of both c-Jun and cyclin D1 is deemed critical for melanoma cell proliferation. This functionality is corroborated by frequently elevated expression and activity of these proteins in human melanomas. Correspondingly, alleviating c-Jun and cyclin D1 function is vital to the success of antimelanoma therapeutics. OBJECTIVES To understand(More)
CRM1-mediated nucleocytoplasmic transport has been shown as a potential anti-cancer target in various malignancies. However, the role of the most characterized CRM1 cofactor RanBP3 in cancer cell biology has never been investigated. Utilizing a loss-of-function experimental setting in a vast collection of genetically varied melanoma cell lines, we witness(More)
Prof. Amulya Kumar Saha was born on January 9, 1913, at Pabna in undivided India, which is now in Bangladesh. His father was also a doctor. Dr. Saha completed his graduation in Science from Calcutta University and after that again did his graduation in medicine from R. G. Kar Medical College, Calcutta.1 After surgical apprenticeship under the most(More)
Current therapy approaches in melanoma targeting have met with the development of resistance and tumour recurrence with a more aggressive phenotype. In a quest for alternative therapy targets, we had previously identified Signal Sequence Receptor 2 (SSR2) as a gene with high expression in a subgroup of human primary melanomas. Now we show that SSR2 exerts a(More)
A clinical study of 40 cases of nerve injuries in neonates with one-year follow-up is presented. The total incidence of such injuries was 1.50%. Thirty-three cases sustained nerve injury due to obstetrical trauma and in 7 cases it was due to postnatal trauma like intragluteal injection and tight splintage. Almost in all cases there was history of prolonged(More)
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