Bhavana Priyadharshini

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The peripheral naïve T cell pool is comprised of a heterogeneous population of cells at various stages of development, which is a process that begins in the thymus and is completed after a post-thymic maturation phase in the periphery. One hallmark of naïve T cells in secondary lymphoid organs is their unique ability to produce TNF rapidly after activation(More)
Foxp3 + regulatory T cells (T regs) are required for immune homeostasis. One notable distinction between conventional T cells (T conv) and T regs is differential phosphatidylinositol 3-kinase (PI3K) activity: only T conv downregulate PTEN, the primary negative regulator of PI3K, upon activation. Here, we show that control of PI3K in T regs is essential for(More)
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