Learn More
We consider the problem of off-line throughput maximization for job scheduling on one or more machines, where each job has a release time, a deadline and a profit. Most of the versions of the problem discussed here were already treated by Bar-Noy et al. [3]. Our main contribution is to provide algorithms that do not use linear programming, are simple and(More)
Reconstruction of sibling relationships from genetic data is an important component of many biological applications. In particular, the growing application of molecular markers (microsatellites) to study wild populations of plant and animals has created the need for new computational methods of establishing pedigree relationships, such as sibgroups, among(More)
In this paper, we investigate the test set problem and its variations that appear in a variety of applications. In general, we are given a universe of objects to be " distinguished " by a family of " tests " , and we want to find the smallest sufficient collection of tests. In the simplest version, a test is a subset of the universe and two objects are(More)
Given a graph of interactions, a module (also called a community or cluster) is a subset of nodes whose fitness is a function of the statistical significance of the pairwise interactions of nodes in the module. The topic of this paper is a model-based community finding approach, commonly referred to as modularity clustering, that was originally proposed by(More)
I do not believe that the accident of birth makes people sisters and brothers. It makes them sib-lings. Gives them mutuality of parentage. Abstract New technologies for collecting genotypic data from natural populations open the possibilities of investigating many fundamental biological phenomena, including behavior , mating systems, heritabilities of(More)
There is convincing evidence for the known and unambiguously accepted beneficial effects of glucocorticoids at low dosages. However, the implementation of existing recommendations and guidelines on the management of glucocorticoid therapy in rheumatic diseases is lagging behind. As a first step to improve implementation, we aimed at defining conditions(More)
Executive summary Scope and purpose GCA is the commonest of all the vasculitides. Visual loss occurs in up to one-fifth of patients, which may be preventable by prompt recognition and treatment [1,2]. The aim of these guidelines is to encourage the prompt diagnosis and management of GCA, with emphasis on the prevention of visual loss. Their scope is to(More)
OBJECTIVE To evaluate the impact of polymyalgia rheumatica (PMR) on clinical outcomes and quality of life (QOL); the relationship between laboratory measures and clinical outcomes, and changes in QOL; and agreement between rheumatologists in confirming the initial diagnosis. METHODS We conducted a prospective study of 129 participants in 8 hospitals in(More)
Executive summary Scope and purpose PMR is the most common inflammatory rheumatic disease in the elderly and is one of the biggest indications for long-term steroid therapy. There are difficulties in diagnosis, with heterogeneity in presentation, response to steroids and disease course. The aim of these guidelines is a safe and specific diagnostic process(More)
OBJECTIVE To prospectively evaluate the disease course and the performance of clinical, patient-reported outcome (PRO) and musculoskeletal ultrasound measures in patients with polymyalgia rheumatica (PMR). METHODS The study population included 85 patients with new-onset PMR who were initially treated with prednisone equivalent dose of 15 mg daily tapered(More)