Bhari Sharanesha Manjunatha

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Several tumors exhibit pH gradient reversal, with acidification of extracellular pH (pHe) and alkalinization of intracellular pH (pHi). The pH gradient reversal is evident even during the preliminary stages of tumorigenesis and is crucial for survival and propagation of tumors, irrespective of their pathology, genetics and origins. Moreover, this hallmark(More)
BACKGROUND Collagen is a part of structural connective tissue in every organ of the body. Study of collagen brings into focus the current knowledge of biosynthesis and degradation as a complex mechanism. One of the major aspects of tumor cell invasion and metastasis is the interaction between cancer cells and extracellular matrix component. Property of(More)
Non-Hodgkin's lymphoma (NHL) commonly presents as non-tender, enlarged lymph nodes, accompanied by diffuse symptoms of fatigue and low-grade intermittent fever and it is derived predominantly from the cells of the B lymphocyte series. NHL cases occur extra-nodally and in 3% of these cases the initial presentation may be in the oral cavity. Though(More)
Benign osteoblastoma (OB) is a rare tumor of bone representing less than 1% of all tumors of the maxillofacial region. Vertebral column, sacrum, long bones, and calvarium are more frequent sites of this tumor. Clinically, patients present with pain and swelling. Histologically, contain a well vascularized, osteoblastic connective tissue stroma and(More)
A tooth is ectopic if it is malpositioned due to congenital factors or displaced by the presence of pathology. Recent literature review suggests only 14 cases of ectopic mandibular third molar in the condylar region. Most have been treated using an extra-oral or endoscopic approach. Patients with an ectopic tooth impaction can remain asymptomatic over the(More)
A growing number of medically compromised patients are encountered by dentists in their practices. Opportunistic fungal infections such as mucormycosis usually occur in immunocompromised patients but can infect healthy individuals as well. Mucormycosis is an acute opportunistic, uncommon, frequently fatal fungal infection, caused by a saprophytic fungus(More)
Lipomas are benign soft tissue tumours composed mainly of mature adipose tissue. Histological variants of lipomas have been named according to the type of tissue present and they include fibrolipoma, angiolipoma, osteolipoma, chondrolipoma and others. Osteolipoma, a classic lipoma with osseous metaplasia, is a very rare histological variant. Owing to the(More)
Central ossifying fibroma is a benign neoplasm, having slow growing nature. Some rare lesions show very aggressive nature, multifocal appearance and reach up to a very massive size. So, these kinds of cases require special attention for their treatment. A unique case of central ossifying fibroma with aggressive nature, multifocal appearance is reported.(More)
Erythema Multiforme, (EM) an uncommon, acute inflammatory reactive mucocutaneous disorder and primary allergies confined to the oral mucosa. However the subsequent attacks can produce more severe forms of EM involving the skin. Manifestations of EM are varied and present a diagnostic dilemma because infections (particularly herpes simplex and mycoplasma(More)
The developing dentition is used to assess maturity and estimate the age in many disciplines including anthropology, archeology, forensic science, pediatric dentistry and orthodontics. There is evidence that dental development is less effected than skeletal development by malnutrition and hormonal disorders. There are two methods of dental age assessment,(More)