Bharat N. Nathwani

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Pathfinder is an expert system that assists surgical pathologists with the diagnosis of lymph-node diseases. The program is one of a growing number of normative expert systems that use probability and decision theory to acquire, represent, manipulate, and explain uncertain medical knowledge. In this article, we describe Pathfinder and our research in(More)
BACKGROUND Adolescent/young adult Hodgkin lymphoma (AYAHL) survivors report fewer exposures to infections during childhood compared with controls, and they have functional lymphocyte aberrations. The gut microbiota plays a central role in immunity. METHODS We investigated whether fecal microbial diversity differed between 13 AYAHL survivors and their(More)
We address practical issues concerning the construction and use of decision-theoretic or normative expert systems for diagnosis. In particular, we examine Pathfinder, a normative expert system that assists surgical pathologists with the diagnosis of lymph-node diseases, and discuss the representation of dependencies among pieces of evidence within this(More)
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We present an evaluation of the diagnostic accuracy of Pathfinder, an expert system that assists pathologists with the diagnosis of lymph node diseases. We evaluate two versions of the system using both informal and decision-theoretic metrics of performance. In one version of Pathfinder, we assume incorrectly that all observations are conditionally(More)
A criticism of diagnostic systems, which are based on the formal foundations of probability and utility, is that their reasoning strategies and recommendations are inflexible and unnatural. We have developed a facility that increases the flexibility of normative reasoning systems by providing multiple human-oriented perspectives on diagnostic problem(More)
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