Bharanidhar Chandrasekaran

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Pregnancy is characterized by a higher incidence of pulmonary embolism (PE) than in age-matched nonpregnant women. However, the diagnosis of PE during pregnancy might prove to be more difficult than in the general population. Clinicians strongly rely on imaging studies to establish a prompt diagnosis. On reviewing this article, the reader will learn the(More)
The interaction between high concentrations of 1-beta-D-arabinofuranosyluracil (HiCAU) and 1-beta-D-arabinofuranosylcytosine (ara-C) was investigated in vivo with emphasis on cell kinetics, pharmacokinetics, and drug metabolism. Mice bearing L5178Y leukemia were given a 48-h s.c. infusion of high-dose ara-U (HiDAU) to achieve a plasma level of 0.5 to 1 mM.(More)
Mice bearing the P388/S or P388/ADR (doxorubicin-resistant) leukemia were treated with menogaril or mitoxantrone. Both drugs were highly effective against P388/S but were ineffective against the doxorubicin-resistant subline, indicating cross-resistance. These observations may be of use in the design of clinical trials with these drugs.
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