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We have used affinity labeling, site-directed mutagenesis and regional chemical mutagenesis in order to determine regions of the human estrogen receptor (ER) important in hormone binding, ligand discrimination between estrogens and antiestrogens, and transcriptional activation. Affinity labeling studies with the antiestrogen, tamoxifen aziridine and the(More)
Antiestrogens, acting via the estrogen receptor (ER) evoke conformational changes in the ER and inhibit the effects of estrogens as well as exerting anti-growth factor activities. Although the binding of estrogens and antiestrogens is mutually competitive, studies with ER mutants indicate that some of the contact sites of estrogens and antiestrogens are(More)
  • Westinghouse Schlumberger-Doll, Bell Helicopter, Alcan Bp, America Defelsko, Raytheon Sofratest, Bhardwaj +14 others
  • 1999
Redefining the limits of ultrasound …a team of scientists, engineers, skilled technicians, and clients. YEAR MILESTONE 1977 Unipolar λ-series transducers for extremely high resolution and spectroscopy. 1978 Dual damping mechanism for high signal-to-noise ratios. 1979 Optimum development of broad-band (W-series), medium-band (P-series), and narrow-band(More)
INTRODUCTION The aim of this study was to evaluate audiological outcomes following adenoidectomy by the classical method and by endoscopically-assisted adenoidectomy using a powered instrument (microdebrider). MATERIALS AND METHODS This study was conducted in a tertiary care center. It included 40 patients divided into two equal groups of 20 each. Group-A(More)
  • B Bhardwaj, P Panda, S Revannasiddaiah, H Bhardwaj
  • 2013
Abducens nerve palsy is a known but rare complication of a few bacterial and viral infections like Mycoplasma pneumonia, cytomegalovirus, Epstein-Barr virus, Hanta virus, herpes zoster, and measles. Abducens nerve palsy due to scrub typhus is extremely rare and so far only one case has been reported in the literature. Scrub typhus is a febrile illness(More)
INTRODUCTION Cardiovocal hoarseness (Ortner's syndrome) is hoarseness of voice due to recurrent laryngeal nerve involvement secondary to cardiovascular disease. Recurrent laryngeal nerve in its course (especially the left side) follows a path that brings it in close proximity to numerous structures. These structures interfere with its function by pressure(More)
Biotinidase deficiency is an inborn error of metabolism that is transmitted as an autosomal recessive disorder. Symptoms include hearing loss, ataxia, blindness, mental retardation, and seizures. The metabolic defect is an inability to recycle the vitamin biotin, which is an important cofactor in key enzymes. We therefore sought to develop an animal model(More)
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