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  • Talin Robinson, Silvia N. Kariuki, +14 authors Timothy B Niewold
  • Medicine, Biology
  • The Journal of Immunology
  • 2011 (First Publication: 1 August 2011)
  • Increased IFN-α signaling is a heritable risk factor for systemic lupus erythematosus (SLE). IFN induced with helicase C domain 1 (IFIH1) is a cytoplasmic dsRNA sensor that activates IFN-α pathwayExpand
  • Rafah Salloum, Beverly S. Franek, +5 authors Timothy B Niewold
  • Medicine
  • Arthritis and rheumatism
  • 2010 (First Publication: 1 February 2010)
  • OBJECTIVE Interferon-alpha (IFNalpha) is a heritable risk factor for systemic lupus erythematosus (SLE). Genetic variation near IRF7 is implicated in SLE susceptibility. SLE-associated autoantibodiesExpand
  • Corinna E Weckerle, Beverly S. Franek, +8 authors Timothy B Niewold
  • Medicine
  • Arthritis and rheumatism
  • 2011 (First Publication: 1 April 2011)
  • OBJECTIVE Interferon-α (IFNα) is a primary pathogenic factor in systemic lupus erythematosus (SLE), and high IFNα levels may be associated with particular clinical manifestations. The prevalence ofExpand
  • T. Niewold, J. Kelly, +25 authors J. Harley
  • Medicine
  • Annals of the rheumatic diseases
  • 2012 (First Publication: 16 November 2011)
  • Objective High serum interferon α (IFNα) activity is a heritable risk factor for systemic lupus erythematosus (SLE). Auto-antibodies found in SLE form immune complexes which can stimulate IFNαExpand
  • Silvia N. Kariuki, Beverly S. Franek, +7 authors Timothy B Niewold
  • Biology, Medicine
  • Arthritis research & therapy
  • 2010 (First Publication: 26 July 2010)
  • IntroductionSystemic lupus erythematosus (SLE) is a highly heterogeneous disorder, characterized by differences in autoantibody profile, serum cytokines, and clinical manifestations. SLE-associatedExpand
  • Tharian S. Cherian, Silvia N. Kariuki, Beverly S. Franek, Jill P Buyon, R. Michael Clancy, Timothy B Niewold
  • Medicine
  • Arthritis and rheumatism
  • 2012 (First Publication: 1 October 2012)
  • OBJECTIVE Variation in the interferon regulatory factor 5 (IRF5) gene has been associated with risk of developing systemic lupus erythematosus (SLE), and this association is largely dependent uponExpand