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  • Amy N Packer, Yi Xing, Scott Q. Harper, Lesley Jones, Beverly L. Davidson
  • Biology, Medicine
  • The Journal of Neuroscience
  • 2008 (First Publication: 31 December 2008)
  • The transcription factor REST silences neuronal gene expression in non-neuronal cells. In neurons, the protein is sequestered in the cytoplasm in part through binding to huntingtin. PolyglutamineExpand
  • Jodi L. McBride, Ryan L. Boudreau, +9 authors Beverly L. Davidson
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2008 (First Publication: 15 April 2008)
  • Huntington's disease (HD) is a fatal, dominant neurodegenerative disease caused by a polyglutamine repeat expansion in exon 1 of the HD gene, which encodes the huntingtin protein. We and others haveExpand
  • Beverly L. Davidson, Colleen S. Stein, +6 authors Jay A Chiorini
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2000 (First Publication: 28 March 2000)
  • Recombinant adeno-associated virus vectors based on serotype 2 (rAAV2) can direct transgene expression in the central nervous system (CNS), but it is not known how other rAAV serotypes perform as CNSExpand
  • Scott Q. Harper, Patrick D. Staber, +7 authors Beverly L. Davidson
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2005 (First Publication: 19 April 2005)
  • Huntington's disease (HD) is a fatal, dominant neurogenetic disorder. HD results from polyglutamine repeat expansion (CAG codon, Q) in exon 1 of HD, conferring a toxic gain of function on the proteinExpand