Beverly Alston-Smith

Learn More
BACKGROUND Nevirapine (NVP) is widely used in antiretroviral treatment (ART) of HIV-1 globally. The primary objective of the AA5208/OCTANE trial was to compare the efficacy of NVP-based versus lopinavir/ritonavir (LPV/r)-based initial ART. METHODS AND FINDINGS In seven African countries (Botswana, Kenya, Malawi, South Africa, Uganda, Zambia, and(More)
Author contributions: Sherman KE, Sterling R and Butt AA conceived of the study, managed study implementation, provided critical review of the analysis, and wrote the first draft of the manuscript; Kang M and Umbleja T managed study implementation, data collection and data analysis; Sterling R, provided study oversight, critical review of the analysis and(More)
INTRODUCTION Despite the efficacy and tolerability of modern antiretroviral therapy (ART), many patients with advanced AIDS prescribed these regimens do not achieve viral suppression or immune reconstitution as a result of poor adherence, drug resistance, or both. The clinical outcomes of continued ART prescription for such patients have not been well(More)
Background: Toll-like receptors (TLRs) are transmembrane receptors that activate cells of the innate immune systems upon recognition of pathogen-associated molecular patterns. The TLR4 is an essential component of the innate immune response to various microorganisms. We investigated the impact of TLR4 polymorphism on development of opportunistic diseases in(More)
  • 1