Betty Tarnowski

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Recent work demonstrated that a mannose receptor is involved in the phagocytosis of rod outer segments by the rat retinal pigment epithelium (RPE). In this study the binding of soluble mannose-containing ligands by human RPE explants is described. In addition, the authors report the isolation of a mannose receptor from human RPE and describe its(More)
The Mouse Models of Human Cancers Consortium (MMHCC) is a collaborative program designed to derive and characterize mouse models of human malignancies. To enhance information and resource exchange among the MMHCC investigators and other cancer research scientists, the NCI Center for Bioinformatics (NCICB, http://ncicb.nci.nih.gov/) has developed web-based(More)
We report here the presence of a mannose-specific receptor on apical membranes of rat retinal pigment epithelial (RPE) cells. For pinocytic studies, 125I-Mannose-BSA (125I-Man-BSA) was incubated with RPE explants from normal (Long Evans) and dystrophic (pigmented RCS) rat retinas. Normal RPE bound 36.1 ng of ligand and, in the presence of mannan competitor,(More)
The retinal pigment epithelium (RPE) phagocytizes the tips of photoreceptor outer segments (OS) during normal eye function. It is not known what ligand on OS is recognized by the RPE for removal from the interphotoreceptor matrix. It is possible that a sugar residue on a cell surface glycoconjugate of either the OS or RPE mediates the phagocytic(More)
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