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Polycystin-1 (PC-1) has been identified as critical to development of the nervous system, but the significance of PC-1 expression in neurons remains undefined, and little is known of its roles outside the kidney, where mutation results in autosomal dominant polycystic kidney disease (ADPKD). In kidney, PC-1 interacts with cadherins, catenins, and its(More)
The purpose of this investigation was to identify targets for the early diagnosis and predictors of deep venous thrombosis (DVT) and the role of these targets in the formation of venous thrombosis. A model of DVT was constructed in rats. Thromboses and venous walls were sampled for reverse transcription polymerase chain reaction study, and blood was sampled(More)
Backgrounds: Epidemiological studies show that alcohol consumption increases breast cancer risk. However, the mechanism by which alcohol causes this effect is not known. Therefore, our objective is to generate an animal model to find the mechanism by which alcohol increases breast cancer risk. Methods: To determine the effects of alcohol consumption on(More)
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