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Primary hepatocytes of Tupaia belangeri as a potential model for hepatitis C virus infection.
- Xiping Zhao, Zhen-ya Tang, T. Baumert
- Biology, MedicineThe Journal of clinical investigation
- 15 January 2002
It is shown that primary Tupaia hepatocytes can be infected with serum- or plasma-derived HCV from infected humans, as measured by de novo synthesis of HCV RNA, analysis of viral quasispecies evolution, and detection of viral proteins.
Binding of Hepatitis C Virus-Like Particles Derived from Infectious Clone H77C to Defined Human Cell Lines
It is demonstrated that insect cell-derived HCV-LPs bind specifically to defined human cell lines, including lymphoma and hepatoma cell lines but not to mouse cell lines.