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Primary hepatocytes of Tupaia belangeri as a potential model for hepatitis C virus infection.
It is shown that primary Tupaia hepatocytes can be infected with serum- or plasma-derived HCV from infected humans, as measured by de novo synthesis of HCV RNA, analysis of viral quasispecies evolution, and detection of viral proteins.
Binding of Hepatitis C Virus-Like Particles Derived from Infectious Clone H77C to Defined Human Cell Lines
It is demonstrated that insect cell-derived HCV-LPs bind specifically to defined human cell lines, including lymphoma and hepatoma cell lines but not to mouse cell lines.