Betina Heinsbæk Thuesen

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AIM To assess muscular fitness by hand grip strength (HGS) and lower limb extension power (LEP) and to explore associations with age, leisure time physical activity (LTPA) and body composition. STUDY POPULATION A population-based sample of 19-72-year-old men and women were invited to participate in the health survey 'Health2006'. The response rate was(More)
OBJECTIVE This study aimed to examine vitamin D status as a determinant for development of type 2 diabetes and deterioration of glucose homeostasis. RESEARCH DESIGN AND METHODS A random sample of the general population of Copenhagen, Denmark, was taken as part of the Inter99 study. Included were 6,405 men and women aged 30-65 years at baseline (1999-2001),(More)
BACKGROUND Smoking is an important cardiovascular disease risk factor, but the mechanisms linking smoking to blood pressure are poorly understood. METHODS AND RESULTS Data on 141 317 participants (62 666 never, 40 669 former, 37 982 current smokers) from 23 population-based studies were included in observational and Mendelian randomization meta-analyses(More)
Genome-wide association studies have mainly relied on common HapMap sequence variations. Recently, sequencing approaches have allowed analysis of low frequency and rare variants in conjunction with common variants, thereby improving the search for functional variants and thus the understanding of the underlying biology of human traits and diseases. Here, we(More)
BACKGROUND Vitamin D deficiency is associated with an increased risk of all-cause mortality in observational studies. The specific causes of death underlying this association lack clarity. We investigated the association between vitamin D status and cause-specific mortality. METHODS We included a total of 9,146 individuals from the two population-based(More)
BACKGROUND Vitamin D deficiency is associated with increased cardiovascular disease risk in observational studies. Whether these associations are causal is not clear. Loss-of-function mutations in the filaggrin gene result in up to 10% higher serum vitamin D concentrations, supposedly due to a decreased UV-protection of the keratinocytes. We used a(More)
OBJECTIVES Vitamin D deficiency is common among persons with chronic obstructive pulmonary disease (COPD). Whether vitamin D affects the development and deterioration of COPD or is a consequence of the disease lacks clarity. We investigated the association between vitamin D status and prevalent and incident COPD in the general population. METHODS We(More)
Autoimmune thyroid diseases (AITD) are common, affecting 2-5% of the general population. Individuals with positive thyroid peroxidase antibodies (TPOAbs) have an increased risk of autoimmune hypothyroidism (Hashimoto's thyroiditis), as well as autoimmune hyperthyroidism (Graves' disease). As the possible causative genes of TPOAbs and AITD remain largely(More)
T he causes of the worldwide increase in type 1 diabetes (T1D) in children are still largely unknown. In Den-mark, the increase in incidence is steep at 3.4% annually and does not appear to be leveling out (1). Lower levels of 25-hydroxyvitamin D [25(OH)D] have been found in patients with newly diagnosed T1D compared with healthy control subjects, implying(More)