Bethany Dubois

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This paper characterizes the low-affinity ligand binding interactions of a fluorinated volatile anesthetic, isoflurane (CHF2OCHClCF3), with bovine serum albumin (BSA) using 19F-NMR transverse relaxation (T2). 19F-NMR spectra of isoflurane in aqueous BSA reveal a single isoflurane trifluoromethyl resonance, indicative of rapid exchange of isoflurane between(More)
Immunochemical studies have demonstrated that apoprotein B-100 and apoprotein B-48 share some antigenic determinants, but whether they are products of the same gene has remained uncertain. Utilizing a specific mouse monoclonal antibody, MB19, we recently characterized a common form of genetic polymorphism that was expressed in apo-B-100 (Young, S. G.,(More)
There is controversy as to the molecular nature of volatile anesthetic target sites. One proposal is that volatile anesthetics bind directly to hydrophobic binding sites on certain sensitive target proteins. Consistent with this hypothesis, we have previously shown that a fluorinated volatile anesthetic, isoflurane, binds saturably [Kd (dissociation(More)
In 1979 Steinberg and colleagues recognized a unique kindred with normotriglyceridemic hypobetalipoproteinemia (1979. J. Clin. Invest. 64:292-301). We have undertaken an intensive reexamination of this kindred and have studied 41 family members in three generations. In this family we document the presence of two distinct apo B alleles associated with low(More)
We recently characterized a common form of genetic polymorphism in human apolipoprotein (apo) B, using the specific monoclonal antibody MB19 (Young SG, et al. Proc Natl Acad Sci USA 1986; 83:1101-1105). Antibody MB19 binds apo B with one of three distinct patterns of immunoreactivity (strong, intermediate, or weak). These three binding patterns are the(More)
In 1979, Steinberg and colleagues described a unique kindred with familial hypobetalipoproteinemia (Steinberg, D., Grundy, S. M., Mok, H. Y. I., Turner, J. D., Weinstein, D. B., Brown, W. V., and Albers, J. J. (1979) J. Clin. Invest. 64, 292-301). Recently, we demonstrated the existence of an abnormal species of apolipoprotein (apo-) B, apo-B37 (Mr =(More)
The potentiometric and spectroscopic methods were applied to describe the equilibria for the Cu(II), Ni(II), and Co(II), D-galactosamine solutions. The stability constants, the spectral data, and the results obtained earlier precisely defined the binding ability of the aminosugars.
<lb>Zebrafish are model organisms known for their distinctive horizontal<lb>stripes formed by interactions between two types of pigment cells: yel-<lb>low xanthophores and black melanophores. Our research builds upon an<lb>existing agent-based model produced by Volkening and Sandstede that<lb>successfully replicates wild type (WT) stripe formation on the(More)
Concerning a Fe-Mn-Si shape memory alloy, it was thought of magnetic measurements to follow the evolutions with temperature of an as quenched steel before and after a 2.5% prestrain. INTRODUCTION The shape memory effect, related to the reverse E -. y transformation of a single crystal of FeMn-Si, was fist shown by Sato (1). Many works are devoted to(More)
Two shape-memory steels were water quenched after one hour at 873 K to keep a stable austenitic structure at 298 K. The best values of the shape memory recovery were obtained after a 2.5% strain followed by an annealing at 873 K. In fact, immediately a h r water quenching from 1323K, the Fe-Mu-Si alloy did not present the forward y+s transformation. The(More)